First comes a full review of the history of syphilis, comprising more than 400 pages. The author favors the American origin of syphilis. An interesting feature is the presence of portraits of a number of the older syphilographers —Fracastor, Jean Fernel, Ulrich van Hutten, Swediaur, van Swieten and Astrue —followed by a number of the more recent pioneers —Ricord, Rollet, Fournier, Metchnikoff, Roux, Neisser, Schaudinn, Wassermann and Ehrlich. Jeanselme points out some of the gaps still existing in our knowledge, among them the practical impossibility of securing a pure culture of Spirochaeta pallida, the failure of experimental syphilis to add much to our knowledge, the failure of experimental syphilis to explain the mechanism of inherited syphilis and the failure of attempts at vaccination, as well as the use of serotherapy. He believes that the existence of a neurotropic virus has not been proved.
Under experimental syphilis there is adequate mention