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November 1931, Vol 24, No. 5 >
Article | November 1931

LUPUS ERYTHEMATOSUS DISSEMINATUS

WILLIAM H. MOOK, M.D.; RICHARD S. WEISS, M.D.; LEON K. BROMBERG, M.D.
Arch Derm Syphilol. 1931;24(5):786-829. doi:10.1001/archderm.1931.01450010798007.
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Disseminate erythematous lupus was first recognized as a definite clinical syndrome by Kaposi in 1872. Since that time, many cases have been reported and the etiology has been discussed from a number of standpoints. The vast majority of the victims are women. The prognosis is always grave. Over 80 per cent of the undoubted cases of disseminate erythematous lupus that have been reported have resulted fatally within five years. Kaposi originally reported a mortality of 50 per cent.

In recent years this disease has been studied by Goeckerman1 and by Keefer and Felty.2 Most authorities agree that the constitutional symptoms vary markedly. There is a lack of physical endurance years before the cutaneous lesions appear. There are irritability and sensitiveness out of proportion to the apparent physical ailments. Vague, sometimes severe, abdominal complaints are noted. Aches and pains in various joints are common. Moderate to

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AAM 2010;304:1493-1495.
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BMJ 2010;341:c5893-c1494.
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