During recent years quantitative chemical studies of the blood provided medical science with many important data. These studies showed themselves to be valuable in internal diseases (diabetes mellitus, nephritis) as well as in diseases of the skin (chronic eczema, furunculosis, etc.).
Later the cholesterol content of the blood was also determined in different diseases. Although in many diseases one cannot speak of a definite change in the amount of cholesterol, diseases have been recognized which show a tendency to hypercholesteremia or hypocholesteremia
Among the diseases in which hypocholesteremia is often met with is syphilis. From the recent investigations of Rosen and Krasnow,1 who cited a considerable number of articles from the literature on determinations of cholesterol in syphilis, it is obvious that there is a marked tendency to hypocholesteremia in this disease. They obtained the lowest values in untreated patients with primary syphilis, somewhat higher ones in