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FACTORIAL CONCEPT OF HEREDITY IN RELATION TO DISEASE, ESPECIALLY SKIN DISEASE

S. J. HOLMES, Ph.D.
Arch Derm Syphilol. 1930;21(4):558-565. doi:10.1001/archderm.1930.01440100042005.
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The science of genetics has been revolutionized within little more than a quarter of a century. It is no exaggeration to say that more real insight into the mechanism of heredity has been obtained since the rediscovery of Mendel's Law in 1900 than had been acquired in all preceding time. As a result of this rapid advance, few except specialists in genetics have an adequate realization of the changes that have been made in this field. Many concepts have been abandoned and new points of view have been introduced, so it is not surprising that many who write on heredity should still continue to interpret their facts in terms of the outgrown categories of a previous generation.

Following Mendel, geneticists have focused their attention on the transmissions of particular characteristics appearing to behave as units, which can be combined and separated in almost any possible relation. Hence, the expression, "unit

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