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BISMUTH ARSPHENAMINE SULPHONATE:  A NEW SYNTHETIC DRUG FOR INTRAMUSCULAR USE IN THE TREATMENT OF SYPHILIS

PAUL A. O'LEARY, M.D.
Arch Derm Syphilol. 1928;18(3):372-379. doi:10.1001/archderm.1928.02380150036005.
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There has been an unusual amount of discussion of the treatment of syphilis during the last few years. Many of the articles have related to new preparations and methods of treatment. This flurry of reports of therapeutic suggestions, modifications and results has in part, at least, been precipitated by dissatisfaction with the efficacy of the use of arsphenamine in association with mercury or bismuth in many cases of acute syphilis. This is often not the result of the drugs themselves but of their injudicious, insufficient or untimely application. Long periods of observation of a large series of cases from well organized special clinics have shown that in approximately 70 per cent of the cases of acute syphilis, cure may be brought about if the prescribed courses of treatment are completed. This entails a continuous period of treatment over many months without intervals of rest. In justice to these results, it

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