May 1925, Vol 11, No. 5 >

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Article | May 1925

THE EFFECT OF GLUCOSE ON THE STABILIZATION OF SOLUTIONS OF ARSPHENAMIN AND NEO-ARSPHENAMIN

JAY F. SCHAMBERG, M.D.; ANNA M. RULE

Arch Derm Syphilol. 1925;11(5):658-661. doi:10.1001/archderm.1925.02370050081006.

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ABSTRACT

We have attempted in this experiment to determine the extent to which the addition of glucose to solutions of arsphenamin and neoarsphenamin would retard oxidation of the solution, and thus prevent deterioration on standing. Glucose has a distinctly reducing action, and it and other sugars have been employed abroad to stabilize solutions prepared in ampules so that the drug could be dispensed in this form without undergoing degeneration or change. The results indicated below are to be interpreted strictly in accordance with the conditions of the experiment, and do not apply to solutions which are kept in a vacuum in sealed ampules. A later publication will deal with this subject.

There is reason to believe that arsphenamin is therapeutically more active than neo-arsphenamin, dose for dose. Nevertheless, the ease of employment of neo-arsphenamin and the better manner in which it is ordinarily tolerated by patients, have led to its more

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SCHAMBERG JF, RULE AM. THE EFFECT OF GLUCOSE ON THE STABILIZATION OF SOLUTIONS OF ARSPHENAMIN AND NEO-ARSPHENAMIN. Arch Derm Syphilol. 1925;11(5):658-661. doi:10.1001/archderm.1925.02370050081006.

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THE EFFECT OF GLUCOSE ON THE STABILIZATION OF SOLUTIONS OF ARSPHENAMIN AND NEO-ARSPHENAMIN

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