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September 1920, Vol 2, No. 3 >

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Article | September 1920

THE PROVOCATIVE PROCEDURES IN THE DIAGNOSIS OF SYPHILIS

PAUL A. O'LEARY, M.D.
Arch Derm Syphilol. 1920;2(3):348-353. doi:10.1001/archderm.1920.02350090077008.
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In June, 1917, Dr. J. H. Stokes and I1 undertook the study of the effect of a small dose of arsphenamin in provoking a positive Wassermann reaction in previously negative blood serum in 103 cases, paying special attention to the value of the test in the diagnosis of obscure syphilis. I propose to review the results of a second series of 285 cases and of a special group of thirty Wassermann series. The provocation of the Wassermann reaction following an injection of arsphenamin was first suggested by Gennerich2 in 1910; it was confirmed by Milian,3 and later advocated as a useful procedure by other syphilographers of note in this country. Craig4 believes that a normal variation occurs in successive Wassermann tests of the same patient. He does not believe that the fluctuation is due to technical error. Haller,3 however, in a similar review attributed such

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