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Topical Tacrolimus: An Effective Therapy for Zoon Balanitis

Jorge Santos-Juanes, MD, PhD; José Sánchez del Río, MD, PhD; Cristina Galache, MD, PhD; Jorge Soto, MD, PhD
Arch Dermatol. 2004;140(12):1538-1539. doi:10.1001/archderm.140.12.1538.
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Plasma cell balanitis, or Zoon balanitis (ZB), is a chronic, benign, inflammatory process usually involving the glans penis and the prepuce. Different treatments have been attempted with partial success.1

Topical formulations of the immunosuppressant macrolide tacrolimus have proved effective in atopic dermatitis, but the use of topical tacrolimus in other skin diseases has only been partially explored.24 We report 3 cases of ZB treated with tacrolimus ointment.

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Figure.

Zoon balanitis. A, 2 Plaques with a shiny, smooth, red surface can be seen on the lateral aspects of the glans; B, there is no sign of inflammation after 3 weeks of treatment (patient 1).

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