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Correspondence |

Topical Tacrolimus, Genital Lichen Sclerosus, and Risk of Squamous Cell Carcinoma

C. B. Bunker, MD, FRCP; S. Neill, MB, FRCP; R. C. D. Staughton, MB, FRCP
Arch Dermatol. 2004;140(9):1169. doi:10.1001/archderm.140.9.1169-a.
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There have been several recent reports of the apparently successful use of topical tacrolimus in the treatment of genital lichen sclerosus (LSc),14 2 of which have appeared in the Archives of Dermatology.1,2

Genital squamous cell carcinoma is an established risk in the context of a chronic inflammatory scarring dermatosis such as LSc.5,6 All too frequently in situ and invasive carcinoma is unsuspected, misdiagnosed, or diagnosed late, with dire consequences. Several factors contribute to this, including a low index of suspicion and a failure to recognize significant signs, often less florid than the features of the precursor dermatosis such as LSc, that are indicative of neoplastic change.

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Anogenital pruritus: lichen sclerosus in children. Pediatr Ann 2007;36(12):785-91.
Topical interventions for genital lichen sclerosus. Cochrane Database Syst Rev 2011;(12):CD008240.
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