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Correspondence |

Localized Pemphigus Foliaceus Induced by Topical Imiquimod Treatment

Rick Lin, DO, MPH; Dan J. Ladd, Jr, DO; Doreatha Jean Powell, DO; Bill V. Way, DO
Arch Dermatol. 2004;140(7):889-890. doi:10.1001/archderm.140.7.889.
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Drug-induced pemphigus is a well-documented entity. Since the first report of pemphigus activation in 1969, many other drugs that can triggerpemphigus foliaceus have been described in the literature . In the literaturesearch, all of the drugs that have been identified as offending agents havebeen systemic.1,2 Very little has been written about localized pemphigus follaceus induced by topical treatment.

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Figure 1.

Photograph showing the progression of lesions before treatment; blue dotted areas indicate the sites of application

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Figure 2.

Photograph showing the progressionof lesions 5 months after the cessation of imiquimod application.

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