Correspondence |

Identification of Novel Deletion Loci at 1p36 and 9p22-21 in Melanocytic Dysplastic Nevi and Cutaneous Malignant Melanomas

Mahmoud R. Hussein, MD, PhD; Eduardo Roggero, MD; Ralph J. Tuthill, MD; Gary S. Wood, MD; Oscar Sudilovsky, MD, PhD
Arch Dermatol. 2003;139(6):816-817. doi:10.1001/archderm.139.6.816.
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Although loss of heterozygosity (LOH) at the 9p22-21 and 1p36 regions, especially the D1S214 locus, has been established in cutaneous malignant melanomas (CMMs), refined deletional analyses of these regions are still lacking.1,2 Therefore, we analyzed 112 melanocytic skin lesions for LOH at the 1p and 9p regions.

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Sun  MEshleman  JRFerrell  LD  et al.  An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region. Hepatology. 2001;331415- 1424
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Retention of heterozygosity in benign nevi (IFNA) with preserved upper and lower alleles in tumorous (T) and matching normal (N) tissues from the same individual. Loss of heterozygosity in dysplastic nevi (D9S171) and melanomas (D1S489). Tumor DNAs show absence of alleles (arrows) detected in the corresponding normal DNAs from the same individual.

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