Although loss of heterozygosity (LOH) at the 9p22-21 and 1p36 regions, especially the D1S214 locus, has been established in cutaneous malignant melanomas (CMMs), refined deletional analyses of these regions are still lacking.1,2 Therefore, we analyzed 112 melanocytic skin lesions for LOH at the 1p and 9p regions.
Retention of heterozygosity in benign nevi (IFNA) with preserved upper and lower alleles in tumorous (T) and matching normal (N) tissues from the same individual. Loss of heterozygosity in dysplastic nevi (D9S171) and melanomas (D1S489). Tumor DNAs show absence of alleles (arrows) detected in the corresponding normal DNAs from the same individual.
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