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Correspondence |

Identification of Novel Deletion Loci at 1p36 and 9p22-21 in Melanocytic Dysplastic Nevi and Cutaneous Malignant Melanomas

Mahmoud R. Hussein, MD, PhD; Eduardo Roggero, MD; Ralph J. Tuthill, MD; Gary S. Wood, MD; Oscar Sudilovsky, MD, PhD
Arch Dermatol. 2003;139(6):816-817. doi:10.1001/archderm.139.6.816.
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Although loss of heterozygosity (LOH) at the 9p22-21 and 1p36 regions, especially the D1S214 locus, has been established in cutaneous malignant melanomas (CMMs), refined deletional analyses of these regions are still lacking.1,2 Therefore, we analyzed 112 melanocytic skin lesions for LOH at the 1p and 9p regions.

Healy  ERehman  IAngus  BRees  JL Loss of heterozygosity in sporadic primary cutaneous melanoma. Genes Chromosomes Cancer. 1995;12152- 156
Link to Article[[XSLOpenURL/10.1002/(ISSN)1098-2264]]
Boni  RZhuang  ZAlbuquerque  AVortmeyer  ADuray  P Loss of heterozygosity detected on 1p and 9q in microdissected atypical nevi [letter]. Arch Dermatol. 1998;134882- 883
Link to Article[[XSLOpenURL/10.1001/archderm.134.7.882]]
Sun  MEshleman  JRFerrell  LD  et al.  An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region. Hepatology. 2001;331415- 1424
Link to Article[[XSLOpenURL/10.1053/jhep.2001.24751]]
Walker  JGPalmer  JMWalter  MK A genetic model of melanoma tumorigenesis based on allelic losses. Genes Chromosomes Cancer. 1995;12134- 141
Link to Article[[XSLOpenURL/10.1002/(ISSN)1098-2264]]
Clark  WH  JrElder  DEGuerry  DTEpstein  MNGreene  MHVan Horn  M A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol. 1984;151147- 1165
Link to Article[[XSLOpenURL/10.1016/S0046-8177(84)80310-X]]
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Retention of heterozygosity in benign nevi (IFNA) with preserved upper and lower alleles in tumorous (T) and matching normal (N) tissues from the same individual. Loss of heterozygosity in dysplastic nevi (D9S171) and melanomas (D1S489). Tumor DNAs show absence of alleles (arrows) detected in the corresponding normal DNAs from the same individual.

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