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Correspondence | April 2002

Metastatic Silicone Granuloma: Lupus Miliaris Disseminatus Faciei–like Facial Nodules and Sicca Complex in a Silicone Breast Implant Recipient

Kayano Suzuki, MD; Mikako Aoki, MD; Seiji Kawana, MD; Hiko Hyakusoku, MD; Shichirou Miyazawa, MD

Arch Dermatol. 2002;138(4):537-538. doi:10.1001/archderm.138.4.533.

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Silicone granulomas are usually observed near silicone-injected areas.¹^- 2 We describe a patient in whom breast-injected silicone was delivered to multiple organs, including facial skin, salivary glands, bone marrow, and lymph nodes, and caused granulomatous lesions. The patient complained of various signs and symptoms suggestive but not diagnostic of a connective tissue disease, and making a definitive diagnosis was difficult.

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Figure 1.

A, Lupus miliaris disseminatus faciei–like lesions, consisting of flesh-colored or mildly erythematous, 3- to 5-mm nodules, were scattered around both eyelids. B, The biopsy specimen shows some small round vacuoles and foamy macrophages within the epithelioid cell granuloma (hematoxylin-eosin, original magnification ×100).

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Figure 2.

Electron microscopy of a lupus miliaris disseminatus faciei–like nodule of the lower eyelid demonstrates some particles of material within the granulomas, which were revealed by electron probe radiographic analysis to contain silicone (Si).

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Suzuki K, Aoki M, Kawana S, Hyakusoku H, Miyazawa S. Metastatic Silicone Granuloma: Lupus Miliaris Disseminatus Faciei–like Facial Nodules and Sicca Complex in a Silicone Breast Implant Recipient. Arch Dermatol. 2002;138(4):537-538. doi:10.1001/archderm.138.4.533.

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Metastatic Silicone Granuloma: Lupus Miliaris Disseminatus Faciei–like Facial Nodules and Sicca Complex in a Silicone Breast Implant Recipient

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