0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Correspondence |

Diabetic Foot Ulcers and Chlamydia pneumoniae: Innocent Bystander or Opportunistic Pathogen?

Lloyd E. King, Jr, MD, PhD; Tod Bushman, DPM; Charles W. Stratton, MD; William M. Mitchell, MD, PhD
Arch Dermatol. 2001;137(5):671-672. doi:.
Text Size: A A A
Published online

Extract

Chlamydia pneumoniae has not been searched for in cutaneous vessels and wounds although it induces vasculopathy and atherosclerosis in internal vessels. Chlamydia pneumoniae may play a role in the pathogenesis of chronic skin ulcers in diabetics,1 atherosclerosis, and other vasculopathies,2 autoimmune diseases such as multiple sclerosis3 and Reiter disease.4 We cultured and evaluated specimens of diabetic foot ulcers by immunohistochemistry to determine if Chlamydia pneumoniae was present and if specific antimicrobial therapy was helpful in patients with diabetic foot ulcers. Chlamydia pneumoniae was cultured from 4 of 9 patients, and immunostaining with anti–C pneumoniae antibodies detected intracellular inclusions in these samples from the 4 culture-positive diabetic foot ulcers. Chlamydiapneumoniae may be an opportunistic pathogen in chronic diabetic foot ulcers that leads to chronic inflammation, scarring, and poor wound healing.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption

Representative culture evidence of Chlamydia pneumoniae in curettage biopsy samples from diabetic foot ulcers from patient 1. A, Immunofluorescent detection of cytoplasmic inclusions of C pneumoniae (arrowheads) in samples was achieved using primary mouse monoclonal antibody RR402, which is specific for the major outer membrane protein antigen of C pneumoniae (Washington Research Foundation, Seattle) and a fluoresceinated secondary antimouse IgG monoclonal antibody with Evans blue counterstain (original magnification ×100). B, Immunocytochemical localization of chlamydial inclusions was performed using a blend of primary monoclonal antibodies against C pneumoniae lipopolysaccharide and major outer membrane protein antigens (monoclonal blend 807; Chemicon Int, Temecula, Calif). Brown inclusion aggregates of these C pneumoniae antigens (arrowheads) were visualized using a peroxidase-labeled antimouse secondary monoclonal antibody and counterstained with hematoxylin (original magnification ×100).

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
Jobs
brightcove.createExperiences();