The clinical characteristics of 6 patients with PLC are summarized in Table 1. Age of onset ranged from 35 to 64 years, and there was no significant predilection in regard to sex or race. Most patients presented with generalized, erythematous, scaly papules distributed predominantly on the trunk and extremities. Case 5 included hypopigmented macules, a common presentation in black skin. Some patients were asymptomatic while others experienced itching, tenderness, or burning. In the 6 patients tested, the leukocyte count was normal and Sézary cells were not detected at the time of diagnosis. Hematoxylin-eosin–stained paraffin sections from each case showed an interface dermatitis composed of a variably dense, bandlike lymphohistiocytic infiltrate with some tapering into the mid dermis. Basal vacuolar degeneration, dyskeratotic cells, and extravasated erythrocytes were present; cytologic atypia was not seen. Of note, 2 patients had a history of breast cancer and both had been taking hormonal agents prior to developing PLC. In case 3, the diagnosis of PLC was preceded 10 years by the onset of mycosis fungoides (MF) and was followed 1 year later by the diagnosis of LyP. Similarly, PLC in case 6 was preceded by MF. Most patients found symptomatic relief with topical corticosteroid therapy; 1 patient's condition improved with oral minocycline therapy. On follow-up, 4 patients had a chronically remitting and relapsing course; however, 1 patient achieved complete clearance with methotrexate therapy and another had spontaneous resolution of lesions.