The median follow-up was 26 months (mean, 29 months; range, 12-45 months).A clinical response of sarcoidal cutaneous lesions was documented in 10 of12 patients receiving minocycline, with a duration of response ranging from10 to 41 months (median, 17 months; mean, 21.6 months) (Table 2). A complete clearing of cutaneous lesions was observedin 8 patients (Figure 1 and Figure 2). The mean time to reach maximalresponse of cutaneous lesions from the date of onset of minocycline treatmentwas 3.2 months (median, 3 months; range, 1-6 months); clinical improvementwas noticed as early as 1 month after the onset of minocycline treatment in7 patients. No relapse occurred during treatment. The median duration of minocyclinetreatment was 12 months (median, 13.5 months; range, 1-24 months). Minocyclinecould be withdrawn in 7 patients who achieved complete response of cutaneouslesions (cases 1, 2, 3, 5, 6, 7, and 12). Among this latter subgroup of patients,the complete response was maintained for a mean of 15.3 months (median, 13months; range, 1-33 months) from the date of minocycline withdrawal. Threeof these 7 patients (cases 1, 2, and 3) presented with a relapse of cutaneouslesions that occurred 6, 1, and 13 months after the discontinuation of minocyclinetreatment, respectively. Patients presenting with relapsing lesions were furthertreated with doxycycline 200 mg/d, since the incidence of adverse effects,such as hyperpigmentation and dizziness, is known to be much lower in patientswho receive this latter drug than in those treated with minocycline. In these3 latter patients, a complete remission of cutaneous lesions was observedafter 1 to 3 months of doxycycline therapy, without occurrence of any adverseeffect. Furthermore, a clearing of lung infiltrates was noticed on chest radiographyperformed in patient 1, who was being treated with doxycycline.