Chronic idiopathic urticaria (CIU) is a troublesome disorder with anunknown etiological agent. Mast cell activation and release of mediators occurin all forms of urticaria. Although histamine is the principal inflammatorymediator of mast cell derivation, other mediators are freed after mast cellactivation such as cysteinyl leukotrienes (leukotrienes C4, D4, and E4).1 We evaluatethe efficacy and tolerability of an antileukotriene drug, montelukast sodium,2 in relation to fexofenadine hydrochloride, an antihistaminicdrug, in patients affected by CIU.
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This model of variance analysis shows that the reduction of symptomsis highly significant at later times of observation (Friedman test, 72.56; P<.001). The total symptom scores of the patients treated with fexofenadinewere on the average worse than those obtained from the montelukast-treatedpatients (Kruskal-Wallis, 8.18; P<.005), although the reductionin the time of the symptomatic profile is essentially the same for both drugs(the interaction between treatment and time of observation is not significant).t0 Indicates the time of measurement as before treatment began;t1, 10 days after treatment began; t2, 20 days aftertreatment began; and t3, 30 days after treatment began.
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