At 8 days after birth, tissue-engineered skin was applied to the medial aspect of the left leg and knee, the sole of the left foot, the left buttock, and the right elbow. These areas were selected because of the presence of significant erosions (Figure 2, A). No sutures, staples, or other devices were used to hold the tissue-engineered skin to the erosions. Before placement, several incisions were made in all but 1 of the grafts to create slits through which fluid could drain. Since the erosion on the buttock was not as exudative, slits were not done on that graft (Figure 2, B). The grafts were then covered with gauze containing petroleum jelly, nonadherant pads, and elastic gauze bandages. Three days later, the erosions on the left leg, knee, and foot and the erosion on the right elbow were completely healed. The healed sites were thick and opaque, consistent with graft "take," rather than thin and translucent, as seen in early reepithelialization. Most of the area on the left buttock was healed (Figure 2, C). There were no signs of infection, and no other adverse effects were noted. Lesions treated only by conservative measures on the right knee, right buttock, and trunk showed no notable improvement.