Many European studies have documented that thalidomide is an effective treatment for various inflammatory dermatoses, such as cutaneous lupus erythematosus (CLE), that are unresponsive to standard therapy. Knop et al,31 in a study of 60 cases of CCLE, reported that 90% of the patients had a complete or marked response to treatment with thalidomide, 400 mg/d, and that 71% had relapses when thalidomide was withdrawn. Stevens et al32 had similar findings with thalidomide, 50 to 100 mg/d, with various adjustments, if any, in the doses of other oral medications already being used to treat CLE. Improvements were observed within 2 weeks of treatment, and maximum benefits were achieved within 16 weeks. Another study involving 11 patients reported that a maintenance dose of 25 to 50 mg every night or every other night was necessary to prevent relapse.33 Other studies were also published confirming the effectiveness of thalidomide, 100 to 400 mg/d, in the cutaneous treatment of various forms of lupus erythematosus (LE).34- 37 The reported adverse effects in these studies included paresthesia, drowsiness, abdominal disturbances, dry mouth, urticaria, rash, mood changes, circulatory changes, amenorrhea, and edema. Of these, paresthesia, sedation, and constipation were the most common.