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Localized Papular Mucinosis With IgA Nephropathy:  A Case Report FREE

Peng Wang, MD; Hanjun Yang, MD; Yuping Ran, MD, PhD
[+] Author Affiliations

Author Affiliations: Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, People's Republic of China.


Arch Dermatol. 2011;147(5):599-602. doi:10.1001/archdermatol.2011.110.
Text Size: A A A
Published online

ABSTRACT

Background  Papular mucinosis is an idiopathic cutaneous mucinosis. It includes 3 clinicopathologic subsets according to the recent Rongioletti classification: a generalized papular form, a localized form, and atypical forms. The localized form is subdivided into 5 subtypes. The atypical form does not meet the criteria for either the generalized papular form or the localized forms and includes localized forms with monoclonal gammopathy and/or systemic symptoms.

Observations  We describe a 37-year-old man who had multiple small, waxy papular lesions on the neck for 4 years. One year after the lesions first appeared, he developed IgA nephropathy. No paraproteinemia or thyroid dysfunction was observed. Histologic examination of the skin lesions showed mucin deposits in the upper dermis. Alcian blue–positive mucin was also found in the renal interstitium and around some vessels and capillary loops. A diagnosis of localized papular mucinosis with IgA nephropathy (atypical form) was made after the biopsy.

Conclusions  The patient showed an unusual manifestation of localized papular mucinosis with the lesions confined to the neck and IgA nephropathy. Alcian blue staining is a useful way to determine kidney involvement of papular mucinosis.

Figures in this Article

Papular mucinosis (PM) (aka, lichen myxedematosus) is a disorder characterized by lichenoid papules, nodules, and/or plaques due to mucin dermal deposition. In 1953, Montgomery and Underwood1 established a clinical classification of PM with 4 subtypes: (1) generalized lichenoid papular eruptions; (2) discrete papular form; (3) localized or generalized lichenoid plaque form; and (4) urticarial plaques and nodular eruptions. The updated Rongioletti classification2 includes 3 clinicopathologic subsets: (1) generalized PM (scleromyxedema) with systemic manifestations; (2) localized PM without sclerotic features, paraproteinemia, or systemic involvement; and (3) atypical forms, not meeting the criteria for either scleromyxedema or the localized form, including localized forms with paraproteinemia and/or systemic symptoms. The localized form is subdivided into 5 sub-subtypes: (1) discrete PM; (2) acral persistent PM (APPM); (3) self-healing PM (SHPM); (4) PM of infancy; and (5) nodular PM. In this study, we describe a man with PM confined to the neck who later developed IgA nephropathy. The case represents a novel form of localized PM, a “confined” form with renal involvement.

REPORT OF A CASE

A 37-year-old Chinese man presented with multiple small, asymptomatic, waxy papular lesions that had been on his neck for 4 years. Over the years, he had continued to develop new lesions, while the preexisting lesions coalesced into plaques. However, the lesions remained confined to the neck and did not spread to other parts of the body. His family history was negative. A review of systems revealed that 1 year after the lesions' first appearance, he had developed symptoms of flank pain, increased nocturia, hematuria, and albuminuria. There was no hypertension, edema, or other symptoms of chronic kidney disease. Through renal biopsy, he had been diagnosed as having IgA nephropathy (grade II). There was no other systemic involvement. Prednisone was given but was unsatisfactory in controlling both the skin and the renal symptoms. His renal function remained normal during these years.

Skin examination revealed multiple firm, waxy, opalescent, flat-topped, 2- to 4-mm papules. The coalesced papules formed a 12 × 6-cm linear plaque on the neck. There were a few discrete and irregularly distributed papules around the plaque (Figure 1).

Place holder to copy figure label and caption
Figure 1.

The patient presented with multiple firm, opalescent, flat-topped papules on the neck ranging in size from 2 to 4 mm. The coalescence of papules formed a 10 × 6-cm linear plaque.

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METHODS

Routine urinalysis revealed macroalbuminuria and hematuria; the 24-hour urinary protein level was 2.14 g. Routine blood test results, thyroid function, and liver and renal function were all normal. Levels of serum IgG, IgA, IgM, IgE, C4, circulating immune complexes, anti–double-stranded DNA, anti–ribonuclear protein, antinuclear antibody, anti-Sm, anti-Ro (SSA), anti-La (SSB), and Scl-70 antibodies were within normal limits. The patient tested negative for human immunodeficiency virus.

Color Doppler ultrasonographic examination of the thyroid gland showed no abnormalities.

Histologic examination of the skin lesions showed loosely separated collagen fibers in the upper dermis, suggesting mucinous deposition, and some dermal mesenchymal cells within and surrounding the mucinous stroma (Figure 2A). The mucinous stroma stained positively with Alcian blue (pH, 2.5) (Figure 2B) but not with toluidine blue (pH, 7.0). Immunohistochemically, the mesenchymal cells tested strongly vimentin positive (Dako, Carpinteria, California), and some of them were also positive for either CD34 (Dako) or factor XIIIa (Biogenesis Ltd, Poole, England) (Figure 2C and D). The CD34+ cells were found mainly within the mucinous stroma and in the deeper part of the dermis (Figure 2C). Factor XIIIa–positive cells were predominant in the periphery of the mucinous stroma (Figure 2D). The mesenchymal cells tested negative for desmin (Dako) and S-100. (Maixin-Bio, Fuzhou, China).

Place holder to copy figure label and caption
Figure 2.

Histopathologic and immunohistochemical specimens. A, Loosely separated collagen fibers in the upper dermis (hematoxylin-eosin, original magnification ×100). B, Mucinous stroma stained positively with Alcian blue (original magnification ×100). C, Expression of CD34 cells within the mucinous stroma and in the deeper part of the dermis (original magnification ×100). D, Expression of factor XIIIa cells in the periphery of the mucinous stroma (original magnification ×100).

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Histologic examination of the renal tissue showed focal mesangial proliferation, sclerosis, and adhesion of the glomeruli; a moderate fibrous crescent formation could also been seen in the glomeruli. The glomerular capsules showed thickening and layering in the corticomedullary junction, and 10% of the renal tubules were atrophic. There was proliferation of the renal interstitium around the atropic tubules and in the corticomedullary junction (Figure 3). Immunofluorescence analysis showed deposits of IgA, mainly in the mesangium (++), and segmental or focal deposits of IgG in glomeruli (++); IgM, C3, C4, C1q, and fibronectin findings were negative.

Place holder to copy figure label and caption
Figure 3.

Histologic examination of the renal tissue (original magnification ×100 for all panels). Visible are focal mesangial proliferation, sclerosis, and adhesion of the glomeruli; atrophic renal tubules; and proliferation of the renal interstitium. A, Hematoxylin-eosin; B, periodic acid–Schiff stain; C, Masson trichrome stain; and D, periodic acid–silver methenamine stain.

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After processing renal tissue with Alcian blue, we also found positively stained mucin deposits in the renal interstitium around some arterioles, venules, renal tubules, and capillary loops, part of them even projecting into the glomerular capsule, and we found some mucin deposits in the mesangium (Figure 4A and B). These mucinous depositions were shown again through staining with Alcian blue/periodic acid–Schiff (Figure 4C and D). To show the correspondence, we also stained with hematoxylin-eosin (HE). The Alcian blue–positive mucinous depositions corresponded to the HE stain of loosely separated collagen fibers and pale-staining areas. Increased numbers of vimentin-positive spindle-shaped cells were found in the mucinous deposition areas. These cells were negative for CD34 and factor XIIIa.

Place holder to copy figure label and caption
Figure 4.

Histopathologic specimens. Alcian blue (AB)–positive mucin deposits were found in the renal interstitium around some arterioles, venules, and tubules (A, original magnification ×100) and also at the corticomedullary junction (B, original magnification ×400). C, Mucin deposits were found in the capillary loops and projected into the glomerular capsule and in the mesangium with mesangial proliferation (AB–periodic acid–Schiff (PAS) stain, original magnification ×100) (inset, AB-PAS, original magnification ×400).

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We proposed vaporizing the lesions with a carbon dioxide laser, but the patient declined the treatment because he had no cosmetic concerns.

COMMENT

Though Rongioletti and Rebora2 made significant contributions to the clinical classification of PM, there remain many cases that are not well characterized. Borradori et al3 report a case of APPM with IgA monoclonal gammopathy that challenges the view that absence of paraproteinemia is a peculiar characteristic of APPM. Chen et al4 report congenital cutaneous mucinosis with spontaneous regression. And our case also presents such an example. Because the lesions were confined to the neck, we believe it should belong to the localized form, but it cannot be categorized into any of the 5 localized subtypes, especially considering the renal association. Discrete PM is inappropriate because it is characterized by isolated papules, which present in a symmetric disposition, mainly on the trunk and extremities.57 The manifestation of this form is clearly different from our case. It is also necessary to differentiate our patient's condition from mucinous nevus and SHPM. Mucinous nevus presents as asymmetric and localized papules at birth or shortly after birth,8 and SHPM spontaneously resolves within a few weeks or not more than 2 years after onset.9

The histopathologic findings of PM are similar. Alcian blue–positive mucin is often deposited in the upper and mid dermis, and the number of dermal mesenchymal cells is increased.2 Immunohistochemical analyses in some cases of PM have detected CD34+ or factor XIIIa–positive dermal dendritic cells (DDCs) within and surrounding the mucin deposition,1012 suggesting that they might have participated in the dermal deposition of mucin. Because vimentin is a general mesenchymal marker and DDCs have been characterized immunohistochemically by the presence of factor XIIIa13 or CD34,14 we also tested for these immunohistochemical markers. The findings in our case showed that vimentin-positive dermal mesenchymal cells were strongly expressed within and surrounding the mucinous stroma. The CD34+ DDCs were found mainly within the mucinous stroma and in the deeper part of the dermis. Factor XIIIa–positive DDCs were located predominantly in the periphery of the mucinous stroma. These cells tested negative for desmin and S-100. Thus, we concluded that CD34+ DDCs within the mucinous stroma, in combination with factor XIIIa–positive DDCs in the perilesional area, may have participated in the dermal deposition of mucin.

In the classification system of Montgomery and Underwood,1 the discrete papular form and localized form are 2 different subtypes. The localized form, in the Rongioletti classification, does not run a disabling course. In fact, as localized literally means confined or restricted to a particular location, the Rongioletti system likely caused misunderstandings by assigning too many additional definitions to the localized form. We propose adding the localized lichenoid plaque form as a new subtype of the localized papular form described by Rongioletti and Rebora,2 defined as lichenoid plaque eruptions confined or restricted to a particular location, which would describe the lesions in our case. When it has an internal association, as in our case, we classify it as an atypical form.

Although scleromyxedema is associated most frequently with monoclonal gammopathy and various systemic disorders,15 there have been cases of localized PM showing systemic involvement.12,16 They are classified as atypical forms. However, kidney involvement is seldom reported in either the generalized (scleromyxedema) or localized forms (atypical type).17 In 2007, Peeters et al18 reported a patient with scleromyxedema and chronic kidney disease. Biopsy specimen analysis revealed that renal failure was due to accumulation of Alcian blue–positive mucin depositions in the wall of the arterioles, which caused concentric narrowing of the renal arterioles and severe glomerular ischemia.

We think that our patient's history of localized PM was involved with his development of his IgA nephropathy. We tested renal tissue with Alcian blue and found Alcian blue–positive mucin deposition in the renal interstitium and capillary loops. Part of the mucin even projected into the glomerular capsules and was deposited in the mesangium. We also found that the number of vimentin-positive spindle-shaped cells was increased in the mucinous deposition areas. These cells tested negative for CD34 and factor XIIIa, which suggests that they were fibroblasts. The proliferation of fibroblasts can cause mucin deposition in the skin,17 which may also cause mucin deposition in the kidney. As Peeters et al18 reported, mucin deposition around vessels can cause narrowing of renal vessels and glomerular ischemia. It is possible that in our case, the proliferation of fibroblasts in combination with mucin deposition in the renal interstitium and glomeruli caused glomerular sclerosis, interstitial fibrosis, atrophic renal tubules, mesangial proliferation, and crescent formation. The pathologic mechanism that caused the underlying defective fibroblasts that produced mucin may also have caused IgA deposition in the mesangium.

Immunoglobulin A nephropathy, a mesangial proliferative glomerulonephritis characterized by deposition of IgA in the glomerular mesangium, is the most common glomerulonephritis throughout the world.19 The exact pathogenesis of it remains unclear. Various systemic diseases are associated with IgA nephropathy, such as liver failure, rheumatoid arthritis, and Reiter disease. The role of IgA in IgA nephropathy is uncertain. Waldo20 believes that IgA deposition alone is inadequate to explain the pathogenesis of IgA nephropathy because IgG deposition occurs at the site of complement activation and fixation. The IgA in the aggregate actually inhibits complement activation and prevents effective immune complex clearance. Oortwijn et al21 hold the opposite view, that IgA deposition may be one of the initiators of local complement activation in the kidney. We believe that the main cause of nephropathy in our patient was the proliferation of fibroblasts and mucin deposition in the renal interstitium and glomeruli. The IgA deposition in the mesangium may have aggravated it. Because the renal function of our patient was normal, we can easily rule out scleromyxedema-like diseases, such as nephrogenic fibrosing dermopathy or nephrogenic systemic fibrosis, which have been described in patients with stage 4 or 5 chronic kidney disease.22

Treatment of PM is empirical and usually unsatisfactory. Tacrolimus ointment can be used in topical therapy,23 and carbon dioxide laser can also be used to clear mild lesions. In this case, prednisone was used to control nephropathy, but it appeared ineffective in controlling either the lesions or the nephropathy. We proposed vaporizing the lesions with a carbon dioxide laser, but the patient declined the treatment because he did not have any cosmetic concerns. The particular eruption pattern of the lesions and kidney involvement are the main points of interest in this case.

ARTICLE INFORMATION

Correspondence: Yuping Ran, MD, PhD, Dermatovenereology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Wang Hou District, Chengdu, People's Republic of China, 610041 (ranyuping@vip.sina.com).

Accepted for Publication: December 10, 2010.

Author Contributions: Dr Ran had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Wang and Ran. Acquisition of data: Wang and Yang. Analysis and interpretation of data: Wang and Yang. Drafting of the manuscript: Wang. Critical revision of the manuscript for important intellectual content: Yang and Ran. Administrative, technical, and material support: Ran. Study supervision: Ran.

Financial Disclosure: None reported.

Funding/Support: This work was partly supported by grant 20050610058 from the Specialized Research Fund for the Doctoral Program of Higher Education.

Additional Contributions: Lin Wang, MD, aided in describing the biopsy specimens. Fengyuan Li, BSMed, aided in performing and analyzing the findings of immunohistochemical staining.

This article was corrected for an error in the staining mechanism for the inset panel of Figure 4C on May 26, 2011.

REFERENCES

Montgomery  HUnderwood  LJ Lichen myxedematosus; differentiation from cutaneous myxedemas or mucoid states. J Invest Dermatol 1953;20 (3) 213- 236
PubMed
Rongioletti  FRebora  A Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema. J Am Acad Dermatol 2001;44 (2) 273- 281
PubMed Link to Article
Borradori  LAractingi  SBlanc  FVerola  ODubertret  L Acral persistent papular mucinosis and IgA monoclonal gammopathy: report of a case. Dermatology 1992;185 (2) 134- 136
PubMed Link to Article
Chen  CWTsai  TFChang  SPChen  YFHung  CM Congenital cutaneous mucinosis with spontaneous regression: an atypical cutaneous mucinosis of infancy? Clin Exp Dermatol 2009;34 (7) 804- 807
PubMed Link to Article
Coskey  RJMehregan  A Papular mucinosis. Int J Dermatol 1977;16 (9) 741- 744
PubMed Link to Article
Bragg  JSoldano  ACLatkowski  JA Papular mucinosis (discrete papular lichen myxedematosus). Dermatol Online J 2008;14 (5) 14
PubMed
Concheiro  JPérez-Pérez  LPeteiro  CLabandeira  JToribio  J Discrete papular lichen myxoedematosus: a rare subtype of cutaneous mucinosis. Clin Exp Dermatol 2009;34 (8) e608- e610
PubMed Link to Article
Redondo Bellón  PVázquez-Doval  JIdoate  MQuintanilla  E Mucinous nevus. J Am Acad Dermatol 1993;28 (5 Pt 1) 797- 798
PubMed Link to Article
Sperber  BRAllee  JJames  WD Self-healing papular mucinosis in an adult. J Am Acad Dermatol 2004;50 (1) 121- 123
PubMed Link to Article
Wilk  MSchmoeckel  C Cutaneous focal mucinosis—a histopathological and immunohistochemical analysis of 11 cases. J Cutan Pathol 1994;21 (5) 446- 452
PubMed Link to Article
Terui  TAiba  STagami  H Solitary subcutaneous mucinosis surrounded by bizarre-shaped, factor XIIIa-positive cells with intranuclear vacuoles. J Cutan Pathol 1998;25 (5) 271- 274
PubMed Link to Article
Yokoyama  EMuto  M Adult variant of self-healing papular mucinosis in a patient with rheumatoid arthritis: predominant proliferation of dermal dendritic cells expressing CD34 or factor XIIIa in association with dermal deposition of mucin. J Dermatol 2006;33 (1) 30- 35
PubMed Link to Article
Cerio  RGriffiths  CECooper  KDNickoloff  BJHeadington  JT Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin. Br J Dermatol 1989;121 (4) 421- 431
PubMed Link to Article
Nickoloff  BJ The human progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shaped cells in Kaposi's sarcoma. Arch Dermatol 1991;127 (4) 523- 529
PubMed Link to Article
Dinneen  AMDicken  CH Scleromyxedema. J Am Acad Dermatol 1995;33 (1) 37- 43
PubMed Link to Article
Truhan  APRoenigk  HH  Jr Lichen myxedematosus: an unusual case with rapid progression and possible internal involvement. Int J Dermatol 1987;26 (2) 91- 95
PubMed Link to Article
Pomann  JJRudner  EJ Scleromyxedema revisited. Int J Dermatol 2003;42 (1) 31- 35
PubMed Link to Article
Peeters  PPraet  MVan Vlem  BNaeyaert  JMVanholder  R End-stage disease of native kidneys in a patient with biopsy-proven Arndt-Gottron scleromyxoedema and recurrence in the transplanted kidney. Nephrol Dial Transplant 2007;22 (10) 3065- 3069
PubMed Link to Article
Floege  JFeehally  J IgA nephropathy: recent developments. J Am Soc Nephrol 2000;11 (12) 2395- 2403
PubMed
Waldo  FB Role of IgA in IgA nephropathy. J Pediatr 1990;116 (5) S78- S85
PubMed Link to Article
Oortwijn  BDEijgenraam  JWRastaldi  MPRoos  ADaha  MRvan Kooten  C The role of secretory IgA and complement in IgA nephropathy. Semin Nephrol 2008;28 (1) 58- 65
PubMed Link to Article
Mackay-Wiggan  JMCohen  DJHardy  MAKnobler  EHGrossman  ME Nephrogenic fibrosing dermopathy (scleromyxedema-like illness of renal disease). J Am Acad Dermatol 2003;48 (1) 55- 60
PubMed Link to Article
Rongioletti  FZaccaria  ECozzani  EParodi  A Treatment of localized lichen myxedematosus of discrete type with tacrolimus ointment. J Am Acad Dermatol 2008;58 (3) 530- 532
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

The patient presented with multiple firm, opalescent, flat-topped papules on the neck ranging in size from 2 to 4 mm. The coalescence of papules formed a 10 × 6-cm linear plaque.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Histopathologic and immunohistochemical specimens. A, Loosely separated collagen fibers in the upper dermis (hematoxylin-eosin, original magnification ×100). B, Mucinous stroma stained positively with Alcian blue (original magnification ×100). C, Expression of CD34 cells within the mucinous stroma and in the deeper part of the dermis (original magnification ×100). D, Expression of factor XIIIa cells in the periphery of the mucinous stroma (original magnification ×100).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Histologic examination of the renal tissue (original magnification ×100 for all panels). Visible are focal mesangial proliferation, sclerosis, and adhesion of the glomeruli; atrophic renal tubules; and proliferation of the renal interstitium. A, Hematoxylin-eosin; B, periodic acid–Schiff stain; C, Masson trichrome stain; and D, periodic acid–silver methenamine stain.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 4.

Histopathologic specimens. Alcian blue (AB)–positive mucin deposits were found in the renal interstitium around some arterioles, venules, and tubules (A, original magnification ×100) and also at the corticomedullary junction (B, original magnification ×400). C, Mucin deposits were found in the capillary loops and projected into the glomerular capsule and in the mesangium with mesangial proliferation (AB–periodic acid–Schiff (PAS) stain, original magnification ×100) (inset, AB-PAS, original magnification ×400).

Graphic Jump Location

Tables

References

Montgomery  HUnderwood  LJ Lichen myxedematosus; differentiation from cutaneous myxedemas or mucoid states. J Invest Dermatol 1953;20 (3) 213- 236
PubMed
Rongioletti  FRebora  A Updated classification of papular mucinosis, lichen myxedematosus, and scleromyxedema. J Am Acad Dermatol 2001;44 (2) 273- 281
PubMed Link to Article
Borradori  LAractingi  SBlanc  FVerola  ODubertret  L Acral persistent papular mucinosis and IgA monoclonal gammopathy: report of a case. Dermatology 1992;185 (2) 134- 136
PubMed Link to Article
Chen  CWTsai  TFChang  SPChen  YFHung  CM Congenital cutaneous mucinosis with spontaneous regression: an atypical cutaneous mucinosis of infancy? Clin Exp Dermatol 2009;34 (7) 804- 807
PubMed Link to Article
Coskey  RJMehregan  A Papular mucinosis. Int J Dermatol 1977;16 (9) 741- 744
PubMed Link to Article
Bragg  JSoldano  ACLatkowski  JA Papular mucinosis (discrete papular lichen myxedematosus). Dermatol Online J 2008;14 (5) 14
PubMed
Concheiro  JPérez-Pérez  LPeteiro  CLabandeira  JToribio  J Discrete papular lichen myxoedematosus: a rare subtype of cutaneous mucinosis. Clin Exp Dermatol 2009;34 (8) e608- e610
PubMed Link to Article
Redondo Bellón  PVázquez-Doval  JIdoate  MQuintanilla  E Mucinous nevus. J Am Acad Dermatol 1993;28 (5 Pt 1) 797- 798
PubMed Link to Article
Sperber  BRAllee  JJames  WD Self-healing papular mucinosis in an adult. J Am Acad Dermatol 2004;50 (1) 121- 123
PubMed Link to Article
Wilk  MSchmoeckel  C Cutaneous focal mucinosis—a histopathological and immunohistochemical analysis of 11 cases. J Cutan Pathol 1994;21 (5) 446- 452
PubMed Link to Article
Terui  TAiba  STagami  H Solitary subcutaneous mucinosis surrounded by bizarre-shaped, factor XIIIa-positive cells with intranuclear vacuoles. J Cutan Pathol 1998;25 (5) 271- 274
PubMed Link to Article
Yokoyama  EMuto  M Adult variant of self-healing papular mucinosis in a patient with rheumatoid arthritis: predominant proliferation of dermal dendritic cells expressing CD34 or factor XIIIa in association with dermal deposition of mucin. J Dermatol 2006;33 (1) 30- 35
PubMed Link to Article
Cerio  RGriffiths  CECooper  KDNickoloff  BJHeadington  JT Characterization of factor XIIIa positive dermal dendritic cells in normal and inflamed skin. Br J Dermatol 1989;121 (4) 421- 431
PubMed Link to Article
Nickoloff  BJ The human progenitor cell antigen (CD34) is localized on endothelial cells, dermal dendritic cells, and perifollicular cells in formalin-fixed normal skin, and on proliferating endothelial cells and stromal spindle-shaped cells in Kaposi's sarcoma. Arch Dermatol 1991;127 (4) 523- 529
PubMed Link to Article
Dinneen  AMDicken  CH Scleromyxedema. J Am Acad Dermatol 1995;33 (1) 37- 43
PubMed Link to Article
Truhan  APRoenigk  HH  Jr Lichen myxedematosus: an unusual case with rapid progression and possible internal involvement. Int J Dermatol 1987;26 (2) 91- 95
PubMed Link to Article
Pomann  JJRudner  EJ Scleromyxedema revisited. Int J Dermatol 2003;42 (1) 31- 35
PubMed Link to Article
Peeters  PPraet  MVan Vlem  BNaeyaert  JMVanholder  R End-stage disease of native kidneys in a patient with biopsy-proven Arndt-Gottron scleromyxoedema and recurrence in the transplanted kidney. Nephrol Dial Transplant 2007;22 (10) 3065- 3069
PubMed Link to Article
Floege  JFeehally  J IgA nephropathy: recent developments. J Am Soc Nephrol 2000;11 (12) 2395- 2403
PubMed
Waldo  FB Role of IgA in IgA nephropathy. J Pediatr 1990;116 (5) S78- S85
PubMed Link to Article
Oortwijn  BDEijgenraam  JWRastaldi  MPRoos  ADaha  MRvan Kooten  C The role of secretory IgA and complement in IgA nephropathy. Semin Nephrol 2008;28 (1) 58- 65
PubMed Link to Article
Mackay-Wiggan  JMCohen  DJHardy  MAKnobler  EHGrossman  ME Nephrogenic fibrosing dermopathy (scleromyxedema-like illness of renal disease). J Am Acad Dermatol 2003;48 (1) 55- 60
PubMed Link to Article
Rongioletti  FZaccaria  ECozzani  EParodi  A Treatment of localized lichen myxedematosus of discrete type with tacrolimus ointment. J Am Acad Dermatol 2008;58 (3) 530- 532
PubMed Link to Article

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