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NRAS-Mutant Melanoma: Response to Chemotherapy

Christopher W. M. Soon, MD; Alain P. Algazi, MD; Edward N. Cha, MD, PhD; Emma M. Webb, MD; Adil I. Daud, MD
Arch Dermatol. 2011;147(5):626-627. doi:10.1001/archdermatol.2011.85.
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Middleton  MRGrob  JJAaronson  N  et al.  Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol 2000;18 (1) 158- 166
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Devitt  BALiu  WSalemi  R  et al.  Clinical outcome and pathologic features associated with NRAS mutation in cutaneous melanoma. J Clin Oncol 2010;28 ((suppl, abstr 8500)) 15s
Davies  MAStemke-Hale  KLin  E  et al.  Integrated molecular and clinical analysis of AKT activation in metastatic melanoma. Clin Cancer Res 2009;15 (24) 7538- 7546
PubMed Link to Article[[XSLOpenURL/10.1158/1078-0432.CCR-09-1985]]
Cheng  JQLindsley  CWCheng  GZYang  HNicosia  SV The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 2005;24 (50) 7482- 7492
PubMed Link to Article[[XSLOpenURL/10.1038/sj.onc.1209088]]

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