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Correspondence |

Successful Laser Treatment of Vandetanib-Associated Cutaneous Pigmentation

Sara Brooks, MD; W. Marston Linehan, MD; Ramaprasad Srinivasan, MD; Heidi H. Kong, MD
Arch Dermatol. 2011;147(3):364-365. doi:10.1001/archdermatol.2011.30.
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Several patterns of cutaneous hyperpigmentation in patients receiving the multikinase inhibitor vandetanib (ZD6474) were recently described.1 We describe herein a patient with perifollicular dark blue-gray macular hyperpigmentation secondary to vandetanib who was successfully treated with 755-nm Q-switched alexandrite laser.

Kong  HHFine  HAStern  JBTurner  ML Cutaneous pigmentation after photosensitivity induced by vandetanib therapy. Arch Dermatol 2009;145 (8) 923- 925
PubMed Link to Article[[XSLOpenURL/10.1001/archdermatol.2009.177]]
Green  DFriedman  KJ Treatment of minocycline-induced cutaneous pigmentation with the Q-switched Alexandrite laser and a review of the literature. J Am Acad Dermatol 2001;44 (2) (suppl)342- 347
PubMed Link to Article[[XSLOpenURL/10.1067/mjd.2001.103036]]
Alster  TSGupta  SN Minocycline-induced hyperpigmentation treated with a 755-nm Q-switched alexandrite laser. Dermatol Surg 2004;30 (9) 1201- 1204
PubMed Link to Article[[XSLOpenURL/10.1111/dsu.2004.30.issue-9]]
Tsao  HBusam  KBarnhill  RLDover  JS Treatment of minocycline-induced hyperpigmentation with the Q-switched ruby laser. Arch Dermatol 1996;132 (10) 1250- 1251
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.1996.03890340116025]]
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Vandetanib-associated perifollicular blue-gray macules. A, Scattered on forehead prior to laser treatment. B, Decreased macules on the forehead after 4 laser treatments.

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