Correspondence |

Fixed Drug Eruption on the Penis Due to Oxcarbazepine

Christian Schuster, MD; Birger Kränke, MD; Werner Aberer, MD; Peter Komericki, MD
Arch Dermatol. 2011;147(3):362-364. doi:10.1001/archdermatol.2011.32.
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Fixed drug eruption (FDE) is a common cutaneous drug adverse effect characterized by recurrent, sharply demarcated, red to livid maculae that evolve into plaque or bullae and erosions at the same skin or mucosal site after every intake of the causative drug.1,2 Common locations are the lips, oral mucosa, hands, genitals, and perianal area.2 We report a genital FDE caused by the aromatic anticonvulsant oxcarbazepine.

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Figure 1

Erythematous erosive patches on the glans penis induced by oxcarbazepine within 1 week of administration.

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Figure 2

Positive test reaction to oxcarbazepine, 5%, in saline solution in a previous fixed drug eruption lesion site 48 hours after administration.

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