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Correspondence |

Giant-Cell Tumor of Skin With Cytoplasmic Human Telomerase Reverse Transcriptase Expression

Michael Murphy, MD; Philip Kerr, MD
Arch Dermatol. 2011;147(3):359-361. doi:10.1001/archdermatol.2011.40.
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Pathologic findings. A-C, Hematoxylin-eosin–stained specimen from an intradermal multinodular tumor composed of admixed polygonal to spindle cells, osteoclastlike multinucleated giant cells, extravasated erythrocytes, hemosiderin deposition, and foci of osteoid formation (original magnifications ×40 [A], ×100 [B], and ×200 [C]). D and E, By immunohistochemical analysis, multinucleated giant cells were found to be markedly positive for CD68 (D) and weakly positive for factor XIIIa (E) (chromogen: 3,3′-diaminobenzidine, original magnifications ×200). F, Human telomerase reverse transcriptase (hTERT) analysis showed granular cytoplasmic staining but negative nuclear reactivity; insert, nuclear staining for hTERT in basal cell carcinoma, positive control tissue (chromogen: 3-amino-9-ethylcarbazole, original magnifications ×200).

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