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Correspondence |

Giant-Cell Tumor of Skin With Cytoplasmic Human Telomerase Reverse Transcriptase Expression

Michael Murphy, MD; Philip Kerr, MD
Arch Dermatol. 2011;147(3):359-361. doi:10.1001/archdermatol.2011.40.
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Folpe  ALMorris  RJWeiss  SW Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. Mod Pathol 1999;12 (9) 894- 902
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PubMed Link to Article[[XSLOpenURL/10.1097/DAD.0b013e3181b34724]]
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PubMed Link to Article[[XSLOpenURL/10.1038/modpathol.3801015]]
Gebre-Medhin  SBroberg  KJonson  T  et al.  Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone. Cytogenet Genome Res 2009;124 (2) 121- 127
PubMed Link to Article[[XSLOpenURL/10.1159/000207516]]
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PubMed Link to Article[[XSLOpenURL/10.1097/DAD.0b013e31819cf6f4]]
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PubMed Link to Article[[XSLOpenURL/10.1111/cup.2007.34.issue-5]]
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PubMed Link to Article[[XSLOpenURL/10.1080/01913120802034504]]
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Pathologic findings. A-C, Hematoxylin-eosin–stained specimen from an intradermal multinodular tumor composed of admixed polygonal to spindle cells, osteoclastlike multinucleated giant cells, extravasated erythrocytes, hemosiderin deposition, and foci of osteoid formation (original magnifications ×40 [A], ×100 [B], and ×200 [C]). D and E, By immunohistochemical analysis, multinucleated giant cells were found to be markedly positive for CD68 (D) and weakly positive for factor XIIIa (E) (chromogen: 3,3′-diaminobenzidine, original magnifications ×200). F, Human telomerase reverse transcriptase (hTERT) analysis showed granular cytoplasmic staining but negative nuclear reactivity; insert, nuclear staining for hTERT in basal cell carcinoma, positive control tissue (chromogen: 3-amino-9-ethylcarbazole, original magnifications ×200).

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