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Correspondence |

Bullous Fixed Drug Eruption Induced by Intravaginal Metronidazole Ovules, With Positive Topical Provocation Test Findings

María Daniela Hermida, MD; Lorena Consalvo, MD; María Marta Lapadula, MD; Patricia Della Giovanna, MD; Hugo Néstor Cabrera, MD
Arch Dermatol. 2011;147(2):250-251. doi:10.1001/archdermatol.2010.419.
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Short  KAFuller  LCSalisbury  JR Fixed drug eruption following metronidazole therapy and the use of topical provocation testing in diagnosis. Clin Exp Dermatol 2002;27 (6) 464- 466
PubMed Link to Article[[XSLOpenURL/10.1046/j.1365-2230.2002.01067.x]]
Sehgal  VNKhandpur  SSardana  KBajaj  P Bullous fixed drug eruption (BFDE) following per-oral metronidazole. J Eur Acad Dermatol Venereol 2003;17 (5) 607- 609
PubMed Link to Article[[XSLOpenURL/10.1046/j.1468-3083.2003.00722.x]]
Woolfson  ADMalcolm  RKGallagher  R Drug delivery by the intravaginal route. Crit Rev Ther Drug Carrier Syst 2000;17 (5) 509- 555
PubMed Link to Article[[XSLOpenURL/10.1615/CritRevTherDrugCarrierSyst.v17.i5]]
Hanson  JMMcGregor  JAHillier  SL  et al.  Metronidazole for bacterial vaginosis: a comparison of vaginal gel vs. oral therapy. J Reprod Med 2000;45 (11) 889- 896
Shiohara  TMizukawa  Y Fixed drug eruption: a disease mediated by self-inflicted responses of intraepidermal T cells. Eur J Dermatol 2007;17 (3) 201- 208
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Figure 1

Arm lesion showing central blistering.

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Figure 2

Erythematous reaction after performing an epicutaneous test with topical metronidazole.

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