After 2 weeks, the clinical response to topical fluorouracil at the sites of AK was judged based on the presence of erythema, pruritus, and pain or burning. The presence or absence of an inflammatory response in areas of seborrheic distribution was also tabulated. Following discontinuation of fluorouracil treatment, a topical, water-based emulsion (Biafine; Ortho Dermatologics, Skillman, New Jersey) was applied twice daily to treated areas. At a final visit, the degree of inflammation in areas of AK and seborrheic dermatitis was again documented. Statistical analysis was performed using the Fisher exact test to compare the proportions of the 2 independent groups.