We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
skINsight |

In Vivo Imaging of Lichen Nitidus With Confocal Laser Scanning Microscopy

Huaxu Liu, PhD, MD; Shengli Chen, PhD, MD; Zhongxiang Shi, MD; Furen Zhang, PhD, MD
Arch Dermatol. 2011;147(1):142. doi:10.1001/archdermatol.2010.386.
Text Size: A A A
Published online


A 33-year-old man, a 20-year-old woman, and a 10-year-old boy with the clinical diagnosis of lichen nitidus (Figure 1A, Figure 2A, and Figure 3A, respectively) underwent imaging with confocal laser scanning microscopy (CLSM) (Vivascope 1500; Lucid-Tech Inc, Henrietta, New York). The mosaic CLSM images (Figure 1B, Figure 2B, and Figure 3B [3×3 mm, 2×2 mm, and 2×2 mm, respectively]) revealed round, enlarged, well-circumscribed dermal papillae. The basal cell layer over the top of the dilated dermal papilla was poorly refractile, possibly because of the depletion of melanocytic cells. The enlarged dermal papillae were heavily laden with individual highly refractive cells, consistent with melanophages and, possibly, mononuclear cells. These findings appear to be a repeatable CLSM pattern for lichen nitidus. Histologically, these lesions revealed a focal well-circumscribed infiltrate of lymphocytes and histiocytes closely attached to the epidermis as well as rete ridges on the margins of the granuloma, which were elongated to create the “claw clutching a ball” image (Figure 1C, Figure 2C, and Figure 3C).

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

3 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
PubMed Articles