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Correspondence |

Effectiveness of Infliximab for Intralymphatic Histiocytosis With Rheumatoid Arthritis

Masanobu Sakaguchi, MD; Hiroshi Nagai, MD, PhD; Goh Tsuji, MD, PhD; Akio Morinobu, MD, PhD; Shunichi Kumagai, MD, PhD; Chikako Nishigori, MD, PhD
Arch Dermatol. 2011;147(1):131-133. doi:10.1001/archdermatol.2010.407.
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Requena  LEl-Shabrawi-Caelen  LWalsh  SN  et al.  Intralymphatic histiocytosis: a clinicopathologic study of 16 cases. Am J Dermatopathol 2009;31 (2) 140- 151
PubMed Link to Article[[XSLOpenURL/10.1097/DAD.0b013e3181986cc2]]
Okazaki  AAsada  HNiizeki  HNonomura  AMiyagawa  S Intravascular histiocytosis associated with rheumatoid arthritis: report of a case with lymphatic endothelial proliferation. Br J Dermatol 2005;152 (6) 1385- 1387
PubMed Link to Article[[XSLOpenURL/10.1111/bjd.2005.152.issue-6]]
Perdriger  A Infliximab in the treatment of rheumatoid arthritis. Biologics 2009;3183- 191
Kalajian  AHCallen  JP Multicentric reticulohistiocytosis successfully treated with infliximab: an illustrative case and evaluation of cytokine expression supporting anti-tumor necrosis factor therapy. Arch Dermatol 2008;144 (10) 1360- 1366
Zoli  AMassi  GPinnelli  MLo Cuccio  CDCastri  FFerraccioli  G Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. Clin Rheumatol 2010;29 (1) 99- 101
PubMed Link to Article[[XSLOpenURL/10.1007/s10067-009-1287-8]]
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Figure 2.

Immunohistopathologic studies. A, Hematoxylin-eosin staining reveals granulomatous inflammation in the dermis (original magnification ×20); the inset shows that the aggregates are mainly composed of mononuclear cells and appear to be in markedly dilated vessels (original magnification ×200). B, Staining with D2-40 reveals that the vessels are of a lymphatic nature with endothelial hyperplasia (original magnification ×200). C, The predominant cells of the aggregates are CD68 (KP-1)–positive histiocytes (original magnification ×200).

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Figure 1.

Clinical appearance. A, Reddish-brown plaque with edema was present on the right elbow. B, Skin lesion markedly improved after infliximab treatment.

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