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Correspondence | September 20, 2010

Bullous Amyloidosis Complicated by Cellulitis and Sepsis: A Case Report

Kalpana Reddy, MD; Syed Hoda, MD; Adam Penstein, MD; Tarun Wasil, MD; Sheng Chen, MD, PhD
Arch Dermatol. 2010;147(1):126-127. doi:10.1001/archdermatol.2010.381.
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Clinical (A and B), histopathologic (C-E), and direct immunofluorescence (F) images from our patient. A, Erythematous patches and erosions in the axilla. B, Erythematous patches, hemorrhagic bullae, and erosions in the groin and medial thighs. C, Biopsy specimen of the medial thigh shows intradermal vesicle formation with hemorrhage in the upper dermis and interstitial neutrophilic infiltrate throughout the dermis and subcutis (hematoxylin-eosin, original magnification ×10). D, Fine granular eosinophilic material is evident in the papillary dermis (hematoxylin-eosin, original magnification ×20). E, The eosinophilic material is confirmed to be amyloid by Congo red staining, which shows apple green birefringence under polarized microscopy (original magnification ×20). F, Direct immunofluorescence findings are positive for IgG in the papillary dermis (original magnification ×20).

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