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Research Letters |

Neurogenic Rosacea: A Distinct Clinical Subtype Requiring a Modified Approach to Treatment FREE

Tiffany C. Scharschmidt, MD; John M. Yost, MD, MPH; Sam V. Truong, MD; Martin Steinhoff, MD, PhD; Kevin C. Wang, MD, PhD; Timothy G. Berger, MD
[+] Author Affiliations

Author Affiliations: Department of Dermatology, University of California, San Francisco (Drs Scharschmidt, Truong, Steinhoff, Wang, and Berger); School of Medicine, University of Michigan, Ann Arbor (Dr Yost); Los Angeles Medical Center, Kaiser Permanente, Los Angeles, California (Dr Truong); and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California (Dr Wang).


Arch Dermatol. 2010;147(1):123-126. doi:10.1001/archdermatol.2010.413.
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Published online

Rosacea is generally categorized into 4 distinct clinical subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular.1 Granulomatous rosacea, rosacea fulminans, and perioral dermatitis have been described as additional variants.2 Herein we describe 14 patients with rosacea and prominent neurologic symptoms, who represent another distinct subset of rosacea meriting a unique approach to management.

Patients with prominent neurologic symptoms in addition to classic features of rosacea were identified during routine appointments at a major teaching hospital. Details regarding medical history, disease symptoms and triggers, and response to treatments were obtained via clinic visits and telephone interviews. The study was approved by the institutional review board of the University of California, San Francisco.

Twelve of the 14 patients were women, and 12 were white. Mean age at disease onset was 38 years. Prominent symptoms included burning or stinging pain (100% [14 of 14]), erythema (100% [14 of 14]), and flushing (93% [13 of 14]), sometimes accompanied by facial edema (50% [7 of 14]), telangiectasias (50% [7 of 14]), pruritus (43% [6 of 14]), and papules (36% [5 of 14]). Important symptom triggers included heat (93% [13 of 14]), sunlight (93%[13 of 14]), hot showers (79% [11 of 14]), stress (71% [10 of 14]), exercise (64% [9 of 14]), and alcohol consumption (57% [8 of 14]). Use of makeup (50% [7 of 14]), eating spicy foods (43% [6 of 14]), touching skin (36% [5 of 14]), drinking hot beverages (29% [4 of 14]), cold weather (21% [3 of 13]), and humidity (14% [2 of 13]) were less reliable triggers. Notably, 71% of patients experienced relief from cooling via fans or cold compresses or ice applied to the face or held in the mouth (10 of 14). Figure 1 depicts typical examination findings in these patients.

Place holder to copy figure label and caption
Figure 1.

Facial erythema is seen in most patients at baseline and uniformly during flares. Inflammatory papules and pustules and rhinophymatous change are unusual in this subset of patients.

Graphic Jump Location

A notably high percentage of patients had neurologic (43% [6 of 14]) or neuropsychiatric (50% [7 of 14]) conditions, including complex regional pain syndrome, essential tremor, depression, and obsessive-compulsive disorder. Neurovascular disorders, including headaches (71% [10 of 14]) and Raynaud phenomenon (29% [4 of 14]), as well as rheumatologic disorders (36% [5 of 14]), including lupus, rheumatoid arthritis, fibromyalgia, mixed connective tissue disease, and psoriatic arthritis, were also common.

Many patients had tried the following treatments with limited success: topical metronidazole (0 of 12 were helped), topical steroids (1 of 8), and oral antibiotics, usually tetracyclines (4 of 8). Most patients benefitted from neurologically focused treatments (9 of 12), including gabapentin (5 of 11), duloxetine (4 of 6), pregabalin (1 of 4), tricyclic antidepressants (2 of 3), and memantine (2 of 2). Topically formulated neuroleptic agents, including doxepin, glycopyrrolate, amitriptyline, capsaicin, and ketamine, were occasionally effective (3 of 7). Hydroxychloroquine (3 of 5), an antimalarial agent with neuromodulatory effects, and vasoactive agents including β-blockers and alpha-1 adrenergic receptors (2 of 5) were each effective in a subset of patients. Comorbidities, demographic data, and individual treatment responses are summarized in the Table.

We propose that this group of patients with strikingly prominent neurologic symptoms represents an underrecognized subgroup of rosacea that we term neurogenic rosacea. By highlighting and formally naming this subgroup, we hope to increase awareness and recognition of these patients and aid the practicing dermatologist in their therapeutic management.

The cause of rosacea is complex, poorly understood, and likely multifactorial, with significant proposed contributions from dysfunctional cutaneous vasculature and innate immunity.3 We believe neuronal dysregulation is equally integral to rosacea pathogenesis. It may contribute to disease via various mechanisms, such as vasomotor instability, release of proinflammatory neuropeptides, and neuronal injury leading to perceived dysesthesias.4,5 In an individual patient, the relative importance of each of the mechanisms may differ, influencing both the spectrum of clinical symptoms and the optimal treatment strategy.

We propose the diagnostic and treatment algorithm illustrated in Figure 2 as a guide for clinicians in managing a patient with suspected neurogenic rosacea. Patients with prominent vasomotor symptoms, defined clinically by flushing and telangiectasias, may respond to vasoactive medications, including β-blockers, alpha-1 adrenergic blockers, and calcium channel blockers. In addition, laser- and light-based therapies seem to be more effective in this subset of patients.

Place holder to copy figure label and caption
Figure 2.

Proposed diagnostic and treatment algorithm for a patient with rosacea based on clinical-pathologic correlation. In any given patient, more than 1 pathway and treatment method might be important, but identifying individual components can help guide management.

Graphic Jump Location

Patients with inflammatory features such as papules, pustules, or edema may respond, if symptoms are mild, to traditional topical therapies such as metronidazole, azelaic acid, or sulfur. Systemic antibiotics and antimalarial agents used for their anti-inflammatory effect may be useful for nonresponders.

Finally, patients with dysesthesia out of proportion to flushing or inflammation can be difficult to treat and require a unique approach first used to treat disorders such as complex regional pain syndrome and neuropathic itch. In our experience, neuroleptic agents (eg, gabapentin, pregabalin), tricyclic antidepressants, and pain-modifying antidepressants (eg, duloxetine) are the most effective. N-methyl-D-aspartic acid receptor antagonists (eg, memantine), systemic antibiotics, and other topically formulated medications (eg, ketamine, glycopyrrolate, capsaicin) may be helpful in certain cases. Because of the associated heightened sensitivity to heat and sunlight, laser- and light-based interventions should be used with caution.

Because our understanding of this enigmatic subclass of rosacea is extremely limited, further research is clearly needed to better describe the underlying pathophysiologic characteristics and to identify additional effective treatment methods.

Correspondence: Dr Wang, Department of Dermatology, Stanford Medicine Outpatient Center, 450 Broadway, Pavillion B, Fourth Floor, Redwood City, CA 94063 (wangke@derm.ucsf.edu).

Accepted for Publication: July 13, 2010.

Author Contributions: Drs Scharschmidt, Wang, and Berger had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Scharschmidt and Yost contributed equally to this work. Study concept and design: Scharschmidt, Yost, Wang, and Berger. Acquisition of data: Scharschmidt, Yost, Truong, and Steinhoff. Analysis and interpretation of data: Scharschmidt, Yost, Steinhoff, and Wang. Drafting of the manuscript: Scharschmidt, Truong, and Steinhoff. Critical revision of the manuscript for important intellectual content: Steinhoff, Wang, and Berger. Statistical analysis: Yost. Administrative, technical, and material support: Scharschmidt, Truong, and Steinhoff. Study supervision: Scharschmidt, Steinhoff, Wang, and Berger.

Financial Disclosure: Dr Steinhoff serves as a consultant for and holds a research grant and patent with Galderma. Dr Berger is a consultant for Prescription Solutions and serves as a nonsalaried principal investigator in other research studies involving GlaxoSmithKline, Clinsys Clinical Research Inc, Merz Pharmaceuticals, and Pharmanet.

Additional Contributions: Elaine Yu, BA, Susan McGuire, BA, and Chris Walker, JD, provided technical assistance and support.

Wilkin  JDahl  MDetmar  M  et al. National Rosacea Society Expert Committee, Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol 2004;50 (6) 907- 912
PubMed Link to Article
Crawford  GHPelle  MTJames  WD Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol 2004;51 (3) 327- 341
PubMed Link to Article
Yamasaki  KGallo  RL The molecular pathology of rosacea. J Dermatol Sci 2009;55 (2) 77- 81
PubMed Link to Article
Wang  KBerger  T Dermatological neurological interactions. InAminoff  MJed. Neurology and General Medicine. 4th ed. Philadelphia, PA Churchill Livingstone2008;
Roosterman  DGoerge  TSchneider  SWBunnett  NWSteinhoff  M Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev 2006;86 (4) 1309- 1379
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

Facial erythema is seen in most patients at baseline and uniformly during flares. Inflammatory papules and pustules and rhinophymatous change are unusual in this subset of patients.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Proposed diagnostic and treatment algorithm for a patient with rosacea based on clinical-pathologic correlation. In any given patient, more than 1 pathway and treatment method might be important, but identifying individual components can help guide management.

Graphic Jump Location

Tables

References

Wilkin  JDahl  MDetmar  M  et al. National Rosacea Society Expert Committee, Standard grading system for rosacea: report of the National Rosacea Society Expert Committee on the classification and staging of rosacea. J Am Acad Dermatol 2004;50 (6) 907- 912
PubMed Link to Article
Crawford  GHPelle  MTJames  WD Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad Dermatol 2004;51 (3) 327- 341
PubMed Link to Article
Yamasaki  KGallo  RL The molecular pathology of rosacea. J Dermatol Sci 2009;55 (2) 77- 81
PubMed Link to Article
Wang  KBerger  T Dermatological neurological interactions. InAminoff  MJed. Neurology and General Medicine. 4th ed. Philadelphia, PA Churchill Livingstone2008;
Roosterman  DGoerge  TSchneider  SWBunnett  NWSteinhoff  M Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev 2006;86 (4) 1309- 1379
PubMed Link to Article

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