Within approximately 4 hours after the tanning bed radiation exposure, the patient noted increased itchiness of her radiation-exposed skin. The next morning, she experienced severe redness, pain, and the beginnings of blister formations on her radiation-exposed abdomen, back, face, and proximal arms. Moreover, on her lips and in her oral cavity, including in her throat, she developed redness and pain. She also noted mild vaginal irritation. She was afebrile and was able to ingest liquids. The patient then presented to an emergency department at her local hospital. She was thought to have a streptococcal infection or drug eruption and was prescribed intramuscular corticosteroids and oral amoxicillin sodium. She was discharged from the emergency department but she returned approximately 6 hours later because of worsening symptoms. At this time she was hospitalized and within 24 hours, she was intubated and given fluid boluses for episodes of hypotension. A vaginal culture was performed, which did not reveal Staphylococcus aureus or group A streptococcus. Results of a throat culture were negative for the latter. After the cultures were performed, the patient was treated with intravenous vancomycin hydrochloride. Due to her worsening symptoms, the patient was transferred to our medical center. On arrival, she was placed in our burn unit, and dermatology, ophthalmology, and gynecology services were consulted. She was afebrile, and her blood pressure was stable. As shown in Figure 1A and B, the patient exhibited blister formation on the areas exposed to tanning bed radiation, especially the chest, abdomen, proximal arms, and upper back (approximately 35% of the body surface area). Laboratory tests results revealed mild transaminitis (aspartate aminotransferase, 80 U/L [normal, <45 U/L]), but were otherwise normal.