During encounters, sensitivity to potential language and cultural barriers between non-Hispanic physicians and Hispanic patients should be addressed, in part by offering an interpreter when needed. Importantly, skin cancer screening questions such as family history, tanning bed use, history of blistering sunburns, and the presence of changing or “funny-looking” moles should be included as part of the encounter to focus on the need for full-body skin examination (FBSE). These questions are important because Hispanic and non-Hispanic whites share melanoma risk factors. Dermatologists should offer an FBSE to patients at risk and should have the competency to perform FBSE using both visual and dermoscopic inspection. Particular attention should be paid to acral areas because there is a higher incidence of acral lentiginous melanoma and melanoma on extremities among Hispanics.