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Correspondence |

Two Novel H-RAS Mutations Identified in a Child With an Atypical Spitzoid Tumor

Lisa Simi, BSc; Pamela Pinzani, BSc; Francesca Salvianti, BSc; Alessandro Lorenzoni, MD; Carlo Tomasini, MD; Paolo Broganelli, MD; Claudio Orlando, BSc; Mario Pazzagli, BSc; Daniela Massi, MD
Arch Dermatol. 2011;147(4):514-515. doi:10.1001/archdermatol.2011.76.
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Da Forno  PDPringle  JHFletcher  A  et al.  BRAF, NRAS and HRAS mutations in spitzoid tumours and their possible pathogenetic significance. Br J Dermatol 2009;161 (2) 364- 37219438459
Link to Article[[XSLOpenURL/10.1111/bjd.2009.161.issue-2]]
Raspollini  MRAmunni  GVillanucci  A  et al.  c-Kit expression in patients with uterine leiomyosarcomas: a potential alternative therapeutic treatment. Clin Cancer Res 2004;10 (10) 3500- 350315161707
Link to Article[[XSLOpenURL/10.1158/1078-0432.CCR-03-0363]]
Pinzani  PSalvianti  FCascella  R  et al.  Allele specific Taqman-based real-time PCR assay to quantify circulating BRAFV600E mutated DNA in plasma of melanoma patients. Clin Chim Acta 2010;411 (17-18) 1319- 132420576522
Link to Article[[XSLOpenURL/10.1016/j.cca.2010.05.024]]
Barnhill  RL The Spitzoid lesion: rethinking Spitz tumors, atypical variants, ‘Spitzoid melanoma’ and risk assessment. Mod Pathol 2006;19 ((Suppl 2)) S21- S3316446713
Link to Article[[XSLOpenURL/10.1038/modpathol.3800519]]
Bastian  BCLeBoit  PEPinkel  D Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 2000;157 (3) 967- 97210980135
Link to Article[[XSLOpenURL/10.1016/S0002-9440(10)64609-3]]
Massi  DCesinaro  AMTomasini  C  et al.  The spectrum of atypical spitzoid melanocytic tumors: a morphological, mutational and FISH analysis. J Am Acad Dermatol In press
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Figure 1.

Atypical spitzoid tumor in a 9-year-old girl. A, Traumatized 6 × 5-mm pigmented lesion. B, On dermoscopy, the lesion shows a blue-whitish veil, irregular streaks, and central yellowish hue. C, Dome-shaped spitzoid melanocytic proliferation involving the epidermis and extending into the dermis up to 1 mm in thickness. D, Melanocytes are mostly arranged in confluent aggregates featuring a nodular growth in the dermis.

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Figure 2.

Results from H-RAS (exon 3) and B-RAFV600E (exon 15) analysis. A, Electropherogram traces showing the double H-RAS G48R/D92N mutations on exon 3. B, Amplification plots and electropherogram of B-RAFV600E mutation. C, Sequence alignments to evidence the degree of interspecies amino acid conservation at loci where H-RAS mutations have been found in exon 3.

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