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Evidence-Based Dermatology: Research Commentary |

A Randomized Controlled Trial of the Addition of Mycophenolate Mofetil or Placebo to Oral Corticosteroids in the Treatment of Pemphigus Vulgaris Fails to Demonstrate a Significant Difference in the Primary Outcome or Quality of Life

Michael Bigby, MD
Arch Dermatol. 2011;147(4):489-491. doi:10.1001/archdermatol.2011.56.
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REFERENCES
Bigby  MStern  RSBigby  JA An evaluation of method reporting and use in clinical trials in dermatology. Arch Dermatol 1985;121 (11) 1394- 13994051526
Jüni  PAltman  DGEgger  M Systematic reviews in health care: assessing the quality of controlled clinical trials. BMJ 2001;323 (7303) 42- 4611440947
 Critical appraisal for therapy. http://www.cebm.net/index.aspx?o=109721 March2011;
Boutron  IDutton  SRavaud  PAltman  DG Reporting and interpretation of randomized controlled trials with statistically nonsignificant results for primary outcomes. JAMA 2010;303 (20) 2058- 206420501928
Beissert  SWerfel  TFrieling  U  et al.  A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of pemphigus. Arch Dermatol 2006;142 (11) 1447- 145417116835
Chams-Davatchi  CEsmaili  NDaneshpazhooh  M  et al.  Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris. J Am Acad Dermatol 2007;57 (4) 622- 62817583373
Martin  LKWerth  VVillanueva  ESegall  JMurrell  DFMurrell  DF Interventions for pemphigus vulgaris and pemphigus foliaceus. Cochrane Database Syst Rev 2009; (1) CD0062631916027210.1002/14651858.CD006263.pub2

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