0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
This Month in Archives of Dermatology |

Missing Article Title FREE

[+] Author Affiliations

Section Editor: Robin L Travers, MD


Arch Dermatol. 2010;146(11):1218. doi:10.1001/archdermatol.2010.329.
Text Size: A A A
Published online

HIDRADENITIS SUPPURATIVA AND CONCOMITANT PYODERMA GANGRENOSUM

Hidradenitis suppurativa (HS) and pyoderma gangrenosum (PG) have rarely been reported in the same patient. In this case series, Hsiao et al identify 11 patients with an overlapping presentation of HS and PG. A female predominance is noted, and slightly more than half of patients had PG lesions in the same sites affected by their HS. Both diseases are characterized by an intense neutrophil-mediated inflammatory response, and they may share a common dysregulation of the innate immune system. Although systemic corticosteroids remain the first-line treatment for PG, they are rarely used for HS. Anti–tumor necrosis factor and anti–interleukin 1 therapies have been effective in treating both PG and HS and may be used increasingly in the future to treat such patients.

See Article

EARLY WHITE DISCOLORATION OF INFANTILE HEMANGIOMA

Infantile hemangiomas (IHs) are the most common benign vascular tumors of infancy. Ulceration is the most common complication. In this case series, Maguiness et al describe early white discoloration of the surface of the IH that heralded extensive, relentless ulceration. This so-called early white discoloration of IH appears to be highly sensitive and relatively specific for predicting hemangioma ulceration. Especially in infants younger than 3 months, clinicians should be aware of this phenomenon as heralding ulceration rather than early involution. Early excision, topical becaplermin treatment, laser therapy, and oral propranolol were useful in expediting healing and controlling pain.

See Article

DERMOSCOPIC ISLAND

Dermoscopy can be a powerful tool in the diagnosis of melanoma. However, only a few dermoscopic descriptors specific for thin melanomas have been identified. In this evaluation of dermoscopic images of in situ melanomas, invasive melanomas, and atypical nevi, Borsari et al describe a dermoscopic appearance characteristic of thin melanomas. These “dermoscopic islands” (DIs) appear as well-circumscribed areas with a uniform dermoscopic pattern that differs from that of the rest of the lesion. Because DIs were found mainly in early invasive and in situ melanomas, their presence may aid early diagnosis of melanoma.

See Article

“BULLFROG NECK,” A UNIQUE MORPHOLOGIC TRAIT IN HIV LIPODYSTROPHY

Shortly after the US Food and Drug Administration approved protease inhibitors for human immunodeficiency virus (HIV) therapy, clinicians began reporting unique changes in body fat distribution among treated patients. Lipodystrophy (fat loss in the face, arms, and legs) and lipohypertrophy (fat gain in the abdomen and back of the neck) accompanied elevated levels of triglycerides, cholesterol, and glucose. Rarer presentations of lipodystrophy include multiple lipomatoses and suprapubic fat pads. In this case series, Tierney and Hanke describe the dysmorphic features of the increase in neck circumference, or “bullfrog neck,” in patients with HIV lipodystrophy. Given the substantial effect on quality of life and the metabolic consequences, the authors deem further investigation into prevention and treatment of this condition essential.

See Article

THE ASSOCIATION OF BULLOUS PEMPHIGOID WITH CEREBROVASCULAR DISEASE AND DEMENTIA

Bullous pemphigoid (BP) is a debilitating autoimmune bullous disease of the elderly. Various neurologic diseases have been described in association with BP. Although the precise pathologic mechanism remains obscure, BP antigens or their isoforms have been identified in brain and neuronal tissue. Autoantibody cross-reactivity or exposure of hidden antigens in the brain triggering an immune response are possible mechanisms. In this case-control study, Taghipour et al demonstrate that neurologic disorders have a significantly higher prevalence in patients with BP than in control subjects of similar age and that cerebrovascular disease and dementia account for this association. Neurologic disease may be a predisposing factor for BP.

See Article

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

234 Views
0 Citations
×

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs