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Correspondence |

Localized Porokeratosis Secondary to Ionizing Radiotherapy for Prostate Carcinoma

Jonathan Mark Batchelor, MRCP; Kate Fife, MD, FRCP; Nigel Peter Burrows, MD, FRCP
Arch Dermatol. 2010;146(11):1318-1320. doi:10.1001/archdermatol.2010.334.
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Segmental porokeratosis developing after electron beam radiotherapy for follicular lymphoma has been reported once, to our knowledge, in the literature.1 However, the patient in that case could not recall which areas of skin were irradiated, so the association was open to question. We report a second case, which we think demonstrates the association even more convincingly.

James  AJClarke  LEElenitsas  RKatz  K Segmental porokeratosis after radiation therapy for follicular lymphoma. J Am Acad Dermatol 2008;58 (2) ((suppl)) S49- S50
PubMed Link to Article[[XSLOpenURL/10.1016/j.jaad.2006.05.033]]
Happle  R Cancer proneness of linear porokeratosis may be explained by allelic loss. Dermatology 1997;195 (1) 20- 25
PubMed Link to Article[[XSLOpenURL/10.1159/000245678]]
Ibbotson  SH Disseminated superficial porokeratosis: what is the association with ultraviolet radiation? Clin Exp Dermatol 1996;21 (1) 48- 50
PubMed Link to Article[[XSLOpenURL/10.1046/j.1365-2230.1996.d01-177.x]]
Halper  SMedinica  M Porokeratosis in a patient treated with total body electron beam radiation. J Am Acad Dermatol 1990;23 (4, pt 1) 754- 755
PubMed Link to Article[[XSLOpenURL/10.1016/S0190-9622(08)81078-X]]
Romaníi  JPujol  RMCasanova  JMde Moragas  JM Disseminated superficial porokeratosis developing after electron-beam total skin irradiation for mycosis fungoides. Clin Exp Dermatol 1996;21 (4) 310- 312
PubMed Link to Article[[XSLOpenURL/10.1111/ced.1996.21.issue-4]]
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Figure 1

Multiple erythematous scaly lesions, located in a segmental distribution in the natal cleft.

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Figure 2

Skin biopsy specimen showing hyperkeratosis and parakeratosis without generalized dysplasia. The angulated column of parakeratin is associated with underlying hypogranulosis and dyskeratosis (cornoid lamella).

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Figure 3

Radiotherapy planning image showing the single anterior (Ant) and 2 lateral (Lat) radiation fields used. The exit dose of the anterior field can be seen at the lower aspect of the image.

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