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Correspondence |

Regression of Cutaneous Warts in a Patient With WILD Syndrome Following Recombinant Quadrivalent Human Papillomavirus Vaccination

Alexander Kreuter, MD; Tim Waterboer, PhD; Ulrike Wieland, MD
Arch Dermatol. 2010;146(10):1196-1197. doi:10.1001/archdermatol.2010.290.
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In the May 2010 issue of the Archives, Venugopal and Murrell1 described a 31-year-old man who showed rapid clearance of cutaneous warts after having received 3 doses of a recombinant quadrivalent human papillomavirus (HPV) vaccination. We herein describe a severely immunosuppressed woman who experienced a similarly substantial regression of widespread cutaneous warts following vaccination with a quadrivalent HPV-6, -11, -16, and -18 vaccine.

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Figure 1

Clinical presentation of the right hand of the patient with WILD syndrome (disseminated warts, depressed cell-mediated immunity, primary lymphedema, and anogenital dysplasia) before recombinant quadrivalent human papillomavirus vaccination. Disseminated flat warts in a bas relief–like pattern are present, destroying the conventional plantar lines and fingerprints.

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Figure 2

Substantial regression of cutaneous warts 1 year after the last administration of the recombinant quadrivalent human papillomavirus vaccination.

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