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Correspondence |

Successful Treatment of Morgellons Disease With Pimozide Therapy

Erika Elise Reid, BA; Peter A. Lio, MD
Arch Dermatol. 2010;146(10):1191-1193. doi:10.1001/archdermatol.2010.276.
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Patients seen with complaints of fibers extruding from the skin associated with nonspecific dermatologic and neuropsychiatric symptoms have been diagnosed as having Morgellons disease. The cause of Morgellons disease and its relationship to delusional infestation (DI) remain controversial. A heterogeneous diagnosis, DI is the most common delusional disorder in dermatology and shares features with Morgellons disease.1

Harth  WHermes  BFreudenmann  RW Morgellons in dermatology. J Dtsch Dermatol Ges 2010;8 (4) 234- 242
PubMed Link to Article[[XSLOpenURL/10.1111/j.1610-0387.2009.07219_supp.x]]
Johnson  GCAnton  RF Pimozide in delusions of parasitosis. J Clin Psychiatry 1983;44 (6) 233
Koblenzer  CS Pimozide at least as safe and perhaps more effective than olanzapine for treatment of Morgellons disease. Arch Dermatol 2006;142 (10) 1364
PubMed Link to Article[[XSLOpenURL/10.1001/archderm.142.10.1364-b]]
Ungvári  GVladár  K Pimozide treatment for delusion of infestation. Act Nerv Super (Praha) 1986;28 (2) 103- 107
Lorenzo  CRKoo  J Pimozide in dermatologic practice: a comprehensive review. Am J Clin Dermatol 2004;5 (5) 339- 349
PubMed Link to Article[[XSLOpenURL/10.2165/00128071-200405050-00007]]
Freudenmann  RWLepping  P Delusional infestation. Clin Microbiol Rev 2009;22 (4) 690- 732
PubMed Link to Article[[XSLOpenURL/10.1128/CMR.00018-09]]
Drolet  BRousseau  GDaleau  PCardinal  RSimard  CTurgeon  J Pimozide (Orap) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current in native cardiac myocytes. J Cardiovasc Pharmacol Ther 2001;6 (3) 255- 260
PubMed Link to Article[[XSLOpenURL/10.1177/107424840100600306]]
Lee  CSAccordino  RHoward  JKoo  J Psychopharmacology in dermatology. Dermatol Ther 2008;21 (1) 69- 82
PubMed Link to Article[[XSLOpenURL/10.1111/dth.2008.21.issue-1]]
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Figure 1

Linear erosions with crusting on cheeks and erythematous eroded papules on chin.

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Figure 2

Bloody paper towels presented by the patient.

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Figure 3

Resolution of lesions following treatment with pimozide.

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