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Correspondence |

Treatment of Sebaceous Adenoma With Topical Photodynamic Therapy

Sue Kyung Kim, MD; Jae Yeol Lee, MD; You Chan Kim, MD, PhD
Arch Dermatol. 2010;146(10):1186-1188. doi:10.1001/archdermatol.2010.278.
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Szeimies  RMLandthaler  MKarrer  S Non-oncologic indications for ALA-PDT. J Dermatolog Treat 2002;13 ((suppl 1)) S13- S18
PubMed Link to Article[[XSLOpenURL/10.1080/095466302317414654]]
Hongcharu  WTaylor  CRChang  YAghassi  DSuthamjariya  KAnderson  RR Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol 2000;115 (2) 183- 192
PubMed Link to Article[[XSLOpenURL/10.1046/j.1523-1747.2000.00046.x]]
Park  MYKim  YC Classic Kaposi sarcoma treated with intralesional 5-aminolevulinic acid injection photodynamic therapy. Arch Dermatol 2009;145 (10) 1200- 1202
PubMed Link to Article[[XSLOpenURL/10.1001/archdermatol.2009.241]]
Tierney  EBarker  AAhdout  JHanke  CWMoy  RLKouba  DJ Photodynamic therapy for the treatment of cutaneous neoplasia, inflammatory disorders, and photoaging. Dermatol Surg 2009;35 (5) 725- 746
PubMed Link to Article[[XSLOpenURL/10.1111/j.1524-4725.2009.01117.x]]
Juzenas  PJuzeniene  AIani  VMoan  J Depth profile of protoporphyrin IX fluorescence in an amelanotic mouse melanoma model. Photochem Photobiol 2009;85 (3) 760- 764
PubMed Link to Article[[XSLOpenURL/10.1111/php.2009.85.issue-3]]
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Figure 1

Clinical images from both patients. A, The solitary 1.0 × 0.7-cm yellowish papule before treatment in patient 1. B, The same lesion 8 months after 3 sessions of photodynamic therapy (PDT) showed moderate clinical improvement. C, The solitary 1.0 × 0.8-cm yellowish papule before treatment in patient 2. D, The same lesion a month after 6 sessions of PDT showed no definitive clinical improvement.

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Figure 2

Hematoxylin-eosin–stained histopathologic specimens from patient 1. A and B, Well-demarcated irregular sebaceous lobules in the papillary dermis are composed of mature sebaceous cells in the center and basaloid cells at the periphery (original magnifications ×50 and ×100 for panels A and B, respectively). C and D, After 3 sessions of topical photodynamic therapy, the sebaceous lobules with proliferation of basaloid cells are still present (original magnifications ×50 and ×100 for panels C and D, respectively).

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