Our patient qualified to receive financial assistance and was started on etanercept therapy, 50 mg twice weekly. He refused interferon therapy despite recommendation from his gastroenterologist. Quantitative HCV-RNA levels were measured every 6 weeks by using hybridization following reverse transcriptase polymerase chain reaction (Roche Cobas Amplicor HCV Monitor Test, V2.0; SeraCare Life Sciences, Milford, Massachusetts) throughout the course of his psoriasis treatment. Over the past year, HCV-RNA levels became undetectable, serum transaminase levels normalized, and his plaque psoriasis almost cleared. He has continued using etanercept without adverse reactions and maintains a normal review of systems.