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Top-Accessed Article: Photoaging and Chronological Skin Aging FREE

Jin Ho Chung, MD, PhD
Arch Dermatol. 2010;146(10):1124. doi:10.1001/archdermatol.2010.214.
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Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, Voorhees JJ. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462-1470.

This review article summarizes how UV radiation reduces the procollagen synthesis and makes the collagen fibril disorganized in the human skin. Also, the authors explain the roles of the partially degraded collagen fragments and the resultant reduced mechanical tension on fibroblasts in the basal procollagen synthesis in photoaged and chronologically aged skin, as well as how retinoids repair and prevent skin aging. In today's world, every woman and man, regardless of age, is interested in maintaining young and healthy skin. To develop truly effective cosmeceutical products and anti–skin-aging drugs, an understanding of the molecular mechanism of skin aging and photoaging is essential; this is provided very nicely by this article.

From June 2004 through August 2009, this article was viewed 3070 times on the Archives of Dermatology Web site.

Contact Dr Chung at the Department of Dermatology, Seoul National University College of Medicine, Seoul 110-744, Korea (jhchung@snu.ac.kr).

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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