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Cutaneous Sclerosis A Previously Undescribed Manifestation of Sclerosing Mesenteritis FREE

Brian R. Hinds, MD; Soon Bahrami, MD; John M. Bernardi, MD; Jeffrey P. Callen, MD
[+] Author Affiliations

Author Affiliations: Indiana University School of Medicine, Indianapolis (Dr Hinds); and Department of Medicine, Division of Dermatology, University of Louisville School of Medicine, Louisville, Kentucky (Drs Bahrami, Bernardi, and Callen).


Arch Dermatol. 2010;146(9):1009-1013. doi:10.1001/archdermatol.2010.212.
Text Size: A A A
Published online

ABSTRACT

Background  Sclerosing mesenteritis is a rare disease of unknown etiology that is characterized by self-limited, nonspecific inflammation and fibrosis of the mesenteric adipose tissue. Histologic classification characterizes 3 main stages in the evolution of the fibroinflammatory process: mesenteric lipodystrophy (ML), mesenteric panniculitis (MP), and sclerosing (retractile) mesenteritis (SM).

Observations  A 68-year-old woman with biopsy-proven MP presented with multiple asymptomatic, indurated subcutaneous nodules on both arms, as well as 2 indurated plaques on her abdomen. The cutaneous changes preceded the diagnosis of SM by roughly 3 years. The arm lesions were centrally depressed with a prominent groove and a peau d’orange appearance. Biopsy findings revealed a subcutaneous process with almost total replacement of adipocytes by zones of woody sclerosis and fat necrosis identical to that observed in the mesentery. To our knowledge, this manifestation of sclerosing mesenteritis has not been reported previously.

Conclusions  Sclerosing mesenteritis has rarely been associated with extra-abdominal idiopathic fibrosclerotic disorders, but a cutaneous component of SM has never been characterized. The fact that the cutaneous lesions were histopathologically identical to the mesenteric changes and their presence prior to the recognition of intra-abdominal disease suggests that future patients with such lesions might be evaluated for this disorder leading to earlier recognition.

Figures in this Article

Sclerosing mesenteritis (SM) is a rare, self-limited fibroinflammatory condition referred to by various clinical terms including retractile mesenteritis, liposclerotic mesenteritis, mesenteric Pfeifer-Weber-Christian disease (PWCD), xanthogranulomatous mesenteritis, mesenteric lipogranuloma, and systemic nodular panniculitis.1 The complete histologic spectrum includes 3 stages with main features of extensive fat necrosis, non specific chronic inflammation, and subsequent collagen deposition with florid sclerosis. The predominance of each individual histologic feature corresponds to a diagnosis of mesenteric lipodystrophy (ML), mesenteric panniculitis (MP), or SM, respectively.2

In 1924, Jura3 first described a pathologic process characterized by mesenteric fibrosis, and the requisite term sclerosing (and retractile) mesenteritis was born. Numerous presumably synonymous clinical names have been introduced subsequently. To date, neither the pathogenesis nor the etiology are well understood. Sclerosing mesenteritis seems to be most common in the fifth or sixth decade, with the reported average age of diagnosis occurring at ages 60 to 63 years.46 Several retrospective studies have observed the disease 2 to 3 times as frequently in men.46 The most common site of disease involvement is the small bowel mesentery.1,7 Rare involvement of the large bowel may occur in the area of the sigmoid mesocolon.79 Children are typically not affected by SM, perhaps because they have a lesser amount of mesenteric adipose tissue.5,10

No precise causal factors have been elucidated for the possible induction of this rare inflammatory condition. Postulated etiologies are commonly based on a parallel association with mesenteric disease and include previous trauma or abdominal surgery, bacterial infection, vascular factors including ischemia, autoimmune disease, and other idiopathic inflammatory conditions.10,11 Sclerosing mesenteritis has rarely been associated with other idiopathic fibrosclerotic conditions, including idiopathic retroperitoneal fibrosis, idiopathic orbital pseudotumor, mediastinal fibrosis, Reidel’s thyroiditis, sclerosing pancreatitis, and sclerosing cholangitis.8,12 The coexistence of these observations has led to a hypothesis that SM might be a subset of idiopathic fibrosclerotic disorders.11,13 The term multifocal fibrosclerosis has typically been reserved for instances in which 2 separate and distinct fibrosclerotic disorders were diagnosed in the same patient.14 Furthermore, several additional systemic diseases in association with SM were analyzed by Akram et al.8 Rheumatologic diseases, such as Sjögren syndrome, ankylosing spondylitis, and rheumatoid arthritis, were each concurrently observed in approximately 10% of the 92 SM cases. It is important to note that no single dermatologic disease or cutaneous manifestation has been previously reported in patients with SM. Although several malignant diseases (lymphoma, myeloma, breast cancer, lung cancer, melanoma, and colon cancer, renal cell carcinoma, Hodgkin disease, carcinoid tumor, and thoracic mesothelioma)15 have been reported concurrently in patients with SM, the possible mechanism, the specific type of neoplasia, and the definitive causal relationship remain to be elucidated.16

REPORT OF A CASE

A 68-year-old woman presented to our clinic 4 months after exploratory laparoscopy for an incidental, retroperitoneal mass visualized on abdominal computed tomographic (CT) scan. Clinical symptoms prompting the CT scan included an unintentional 9.5-kg weight loss over 6 to 8 weeks with additional symptoms of early satiety, intermittent dysphagia, and vomiting. On surgical exploration, the mass was noted to emanate in the region of the superior mesenteric artery within the root of duodenal mesentery.

Biopsy findings of the mesenteric mass revealed diffuse sclerosis of mesenteric adipose tissue with foci of fat necrosis, lipophages, and patchy chronic inflammation. Macrophage antigen CD68 was diffusely immunopositive, confirming a prominent histiocytic component. Cytokeratins AE1/AE3 and S-100 protein were essentially immunonegative for disease. A second consulting surgical pathologist concurred with the histologic features, and the subsequent diagnosis of MP was established.

The patient's medical history was remarkable for coronary artery disease, hypertension, dyslipidemia, gastroesophageal reflux disease, osteoarthritis, and nephrolithiasis. Her surgical history included the most recent exploratory laparoscopy, 2-vessel coronary artery bypass 13 years prior to presentation, total abdominal hysterectomy 15 years prior, and 3 separate breast biopsies in which the findings were negative for malignant disease. Her family history was negative for cutaneous familial disease or similar symptoms. The patient was a retired factory worker and denied any environmental or job-related toxin exposure. She had stopped smoking 9 years prior to presentation and denied illegal substance abuse. There was no history of L-tryptophan ingestion.

Laboratory findings included a mildly elevated erythrocyte sedimentation rate of 27 mm/h, a mild anemia with hemoglobin level of 10.5 g/dL (reference range, 12.0-16.2 g/dL [includes normal range for males, 13.2-16.2 g/dL, and females, 12.0-15.2 g/dL]), and a positive test result for antinuclear antibody with no titer provided. (To convert hemoglobin to grams per liter, multiply by 10.0.) Eosinophilia was not present. Findings for recent complete metabolic profile and liver function tests were within reference range. Her C-reactive protein level was within reference range. Serologic testing for anti-Ro (SS-A), anti-La (SS-B), anti–Scl-70, and anti–double-stranded DNA antibodies was negative for disease. Imaging findings from chest, abdomen, and pelvic CT scans and upper and lower endoscopies were unremarkable.

At the time of dermatologic evaluation, the patient reported a 3-year history of asymptomatic nodules that gradually increased in size. Two of the 4 upper extremity lesions had arisen on the right lateral upper arm approximately 3 years previously, while the remaining 2 lesions developed 1 year prior to presentation on the left lateral upper arm. In addition, 2 well-demarcated plaques that had arisen 6 months prior to presentation were identified on the lower right abdominal wall.

Physical examination revealed flesh-colored, indurated subcutaneous nodules localized to the upper arms bilaterally. The largest lesion located on the right upper lateral arm measured 2 × 3 cm (Figure 1). There was no erythema, warmth, tenderness, or fluctuance, and the skin surface was intact. The lesions were irregular in shape, with firm, bound-down borders and a central puckered fibrous depression that exhibited an edge of lateral retraction. The arm lesions also exhibited a prominent groove along superficial veins. In contrast, the more recent abdominal skin lesions measured 1.0 × 1.5 cm and were characterized by sclerodermoid induration and hyperpigmentation (Figure 1).

Place holder to copy figure label and caption
Figure 1.

A 68-year-old woman with sclerosing mesenteritis. A, Subcutaneous nodule on the right posterolateral arm exhibits a central fibrous depression with overlying peau d’orange surface changes and lateral retraction. B, Two well-circumscribed plaques on the right lower abdomen with sclerodermoid induration and hyperpigmentation along the borders.

Graphic Jump Location

A 4-mm punch biopsy specimen was obtained from the right upper arm. Multiple sections revealed almost total replacement of subcutaneous fat by well-demarcated zones of woody sclerosis and fat necrosis. Surrounding the islands of sclerosis, there was a mild lymphocytic response admixed with lipophages and histiocytes (Figure 2). Plasma cells were notably absent from the lymphohistiocytic infiltrate. The blood vessels were unremarkable. Patchy calcification was present in some of the sclerotic zones. The epidermis and dermis were essentially unremarkable. Cutaneous biopsy findings demonstrated features almost identical to those seen in the mesenteric adipose tissue (Figure 2).

Place holder to copy figure label and caption
Figure 2.

Cutaneous sign of mesenteric sclerosis. A, Cutaneous sclerosis: well-demarcated islands of subcutaneous sclerosis with almost total envelopment of normal adipose tissue (hematoxylin-eosin, original magnification ×2). B, Cutaneous sclerosis: zones of woody sclerosis with contiguous fat necrosis and a mild lymphohistiocytic response (hematoxylin-eosin, original magnification ×10). C, Sclerosing mesenteritis: florid woody sclerosis predominates over mesenteric fat necrosis (hematoxylin-eosin, original magnification ×4). D, Sclerosing mesenteritis: dense sclerotic collagen bundles in whorled arrangement with foci of mesenteric fat necrosis and a scant lymphocytic response (hematoxylin-eosin, original magnification ×10).

Graphic Jump Location

COMMENT

The clinical differential diagnosis of SM is often complex, and the combined rarity and wide spectrum of disease presentation increases the propensity for its misdiagnosis. Sclerosing mesenteritis must be differentiated from inflammatory pseudotumor, mesenteric fibromatosis, idiopathic retroperitoneal fibrosis, sclerosing fibroma, sclerosing malignant lymphoma, liposarcoma, lymphosarcoma, malignant primary mesenteric tumor, sclerosing peritonitis, reactive fibrosis due to an abscess, Whipple disease, and metastatic neoplasia.4,15,17 In most cases, specific histopathologic features and immunohistochemical stains usually contribute to the precise pathologic diagnosis. Dual-phase CT combined with biopsy and subsequent clinicopathologic correlation aids in making the definitive clinical diagnosis.13

A retrospective study,4 performed by the Armed Forces Institute of Pathology, examined 84 cases of SM, MP, or ML for common histologic and clinical presentations. Three separate histologic components were evaluated and confirmed with the following trends: ML characterized by fat necrosis, MP typified by chronic subcutaneous inflammation, and SM with prominent fibrotic changes.4 With sequential histologic progression of ML to MP, SM represents the most mature inflammatory stage with predominance of sclerotic connective tissue compressing the bowel lumen. In the surrounding background of sclerosis, there is usually extensive fat necrosis and a modest inflammatory infiltrate. However, a mixed histopathologic picture may be identified in some cases, and clear separation into distinct stages remains difficult and provides no beneficial therapeutic correlation for the patient. The relationship between the histologic stage and disease severity remains unclear. Some authors report a more severe clinical progression or duration of disease associated with a histologic predominance of marked fibrosis over chronic inflammation or panniculitis.18

Although SM has rarely been reported in association with other idiopathic fibrosclerotic disorders, to our knowledge the presence of cutaneous involvement has never been previously described. In contrast, the disease entity of PWCD or idiopathic lobular panniculitis has been well characterized by both internal and cutaneous disease progression in a relapsing and remitting fashion.19,20 Like previous authors, we refer to PWCD as a part of the category of disorders erroneously considered as a specific variant of panniculitis.21 In a unique review of 30 cases of PWCD by White and Winkelmann,19 the initial diagnosis of PWCD was clinically suspected in only one-third of the patients. Further microscopic study of all cases yielded features more consistent with a specific histologic diagnosis, such as acute factitial traumatic panniculitis, erythema nodosum variant, lymphoma, or cytophagic panniculitis.19 Regardless of the clinicopathologic diagnosis, none of these cases showed clinical or histologic similarity to the characteristic features of SM.

Considerations in the cutaneous histopathologic differential diagnosis include fat necrosis associated with pancreatitis, lobular idiopathic panniculitis, lupus panniculitis, variants of deep morphea, postirradiation pseudosclerodermatous panniculitis, factitial panniculitis syndromes (ie, factitial paraffinoma), a late-stage fibrotic variant of erythema nodosum, chronic Lyme disease, calciphylactic panniculitis, involutional lipoatrophy, traumatic panniculitis, and panniculitis due to lymphoproliferative disorders.13,1922

The insidious onset of multiple asymptomatic, nodular skin lesions combined with distinctive histologic features of SM, favors a rare, extra-abdominal manifestation of SM. Moreover, the unique cutaneous predominance of subcutaneous woody sclerosis with fat necrosis mitigates against a diagnosis of any one of the previously recognized cutaneous panniculitidies. The absence of plasma cells in the inflammatory infiltrate distinguishes this case from other sclerosing disorders in masquerade, such as postirradiation pseudosclerodermatous panniculitis, immunoglobulin G4–related sclerosing disorders, chronic Lyme disease, and variants of deep morphea.

Clinically, the skin lesions and the intra-abdominal process exhibited chronological and histologic overlap solidifying our diagnosis of cutaneous-sclerosing (retractile) mesenteritis. Our patient had undergone a total abdominal hysterectomy 15 years prior to presentation, which may have increased the propensity for, or triggered, the development of the fibroinflammatory process. The precise causal role of abdominal surgery and other associated factors in the pathogenesis of SM will likely require a higher volume of case observations and necessitate further research. As for reported associations of SM with malignant disease, in particular lymphoproliferative disorders, it remains unclear whether there will be a proven role for Curth's postulates in cutaneous SM.15,23 At present, the precise relationship between the skin disease, the bowel disease, and the possible risk of internal malignant disease remains largely unknown.15,24,25

Because it is rare, therapeutic recommendations for SM are based on case reports and small case series. Medical treatment for refractory SM with tamoxifen and prednisone has been reported to have variable success.8 Alternatively, in cases with persistent obstructive symptoms or perforation, surgical correction is indicated.

In sum, we observed asymptomatic subcutaneous nodules in a patient with known fibroinflammatory mesenteric disease. The microscopic appearance was suggestive of a mature histologic stage of SM with features of prominent woody sclerosis and an associated outer-rim of histiocytes most consistent with cutaneous SM. Initially diagnosed as MP, the mesenteric biopsy was further reviewed and, because of the prominent woody sclerosis, is better classified as SM.

Our case suggests an unusual yet specific panniculitis that may be best termed cutaneous sclerosis of SM. Because our patient is asymptomatic, treatment has not been recommended. This case highlights a novel cutaneous progression of visceral disease, and dermatologists should consider cutaneous sclerosis as a marker of SM in the concurrent setting of SM and a rare cutaneous sclerosing panniculitis.

ARTICLE INFORMATION

Correspondence: Jeffrey P. Callen, MD, University of Louisville School of Medicine, Department of Medicine, Division of Dermatology, 310 E Broadway, Ste 2A, Louisville, KY 40202 (jefca@aol.com).

Accepted for Publication: March 12, 2010.

Author Contributions: All authors had full access to all the data in this case series and take full responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Hinds, Bernardi, and Callen. Acquisition of data: Hinds, Bahrami, Bernardi, and Callen. Analysis and interpretation of data: Bahrami and Callen. Drafting of the manuscript: Hinds, Bernardi, and Callen. Critical revision of the manuscript for important intellectual content: Bahrami and Callen. Administrative, technical, and material support: Callen. Study supervision: Bahrami, Bernardi, and Callen.

Financial Disclosure: Dr Callen has consulted for Amgen, Abbott, Centocor, Medicis, Celgene, and Electrical Optical Sciences.

Disclaimer: Dr Callen is the associate editor of the Archives but had no involvement in the review or selection of this paper for publication. Dr Bahrami is on the editorial board of the Archives but had no involvement in the review or selection of this article for publication.

Additional Contributions: We are grateful to Paul Schneider, MD, who referred this patient for our assessment and care.

REFERENCES

Chawla  SYalamarthi  SShaikh  IATagore  VSkaife  P An unusual presentation of sclerosing mesenteritis as pneumoperitoneum: case report with a review of the literature. World J Gastroenterol 2009;15 (1) 117- 120
PubMed Link to Article
Edwards  MASmith  MParker  WGu  K Mesenteric lipodystrophy of the left colon. Am Surg 2007;73 (12) 1242- 1244
PubMed
Jura  V Sulla mesenterite e sclerosante. Il Policlinico (Sezione practica) 1924;31575
Emory  TSMonihan  JMCarr  NJSobin  LH Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity? Am J Surg Pathol 1997;21 (4) 392- 398
PubMed Link to Article
Plasencia  L DelgadoRodríguez Ballester  LLópez-Tomassetti Fernández  EMHernández Morales  ACarrillo Pallarés  AHernández Siverio  N Mesenteric panniculitis: experience in our center [in Spanish]. Rev Esp Enferm Dig 2007;99 (5) 291- 297
PubMed
Béchade  DDurand  XDesramé  J  et al.  Etiologic spectrum of mesenteric panniculitis: report of 7 cases [in French]. Rev Med Interne 2007;28 (5) 289- 295
PubMed Link to Article
McCrystal  DJO’Loughlin  BSSamaratunga  H Mesenteric panniculitis: a mimic of malignancy. Aust N Z J Surg 1998;68 (3) 237- 239
PubMed Link to Article
Akram  SPardi  DSSchaffner  JASmyrk  TC Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients. Clin Gastroenterol Hepatol 2007;5 (5) 589- 596
PubMed Link to Article
Adachi  YMori  MEnjoji  MUeo  HSugimachi  K Mesenteric panniculitis of the colon: review of the literature and report of two cases. Dis Colon Rectum 1987;30 (12) 962- 966
PubMed Link to Article
Parra-Davila  EMcKenney  MGSleeman  D  et al.  Mesenteric panniculitis: case report and literature review. Am Surg 1998;64 (8) 768- 771
PubMed
Lim  CSRanger  G SinghTibrewal  SJani  BJeddy  TALafferty  K Sclerosing mesenteritis presenting with small bowel obstruction and subsequent retroperitoneal fibrosis. Eur J Gastroenterol Hepatol 2006;18 (12) 1285- 1287
PubMed Link to Article
Sharma  VMartin  PMarjoniemi  VM Idiopathic orbital inflammation with sclerosing mesenteritis: a new association? Clin Experiment Ophthalmol 2006;34 (2) 190- 192
PubMed Link to Article
Wat  SYHarish  SWinterbottom  AChoudhary  AKFreeman  AH The CT appearances of sclerosing mesenteritis and associated diseases. Clin Radiol 2006;61 (8) 652- 658
PubMed Link to Article
Al-Harthy  FEsdaile  JBerean  KWChalmers  A Multifocal idiopathic fibrosclerosis: treatment of 2 cases with cyclosporine. J Rheumatol 2006;33 (2) 358- 361
PubMed
Issa  IBaydoun  H Mesenteric panniculitis: various presentations and treatment regimens. World J Gastroenterol 2009;15 (30) 3827- 3830
PubMed Link to Article
Daskalogiannaki  MVoloudaki  APrassopoulos  P  et al.  CT evaluation of mesenteric panniculitis: prevalence and associated diseases. AJR Am J Roentgenol 2000;174 (2) 427- 431
PubMed Link to Article
Kelly  JKHwang  WS Idiopathic retractile (sclerosing) mesenteritis and its differential diagnosis. Am J Surg Pathol 1989;13 (6) 513- 521
PubMed Link to Article
Vettoretto  NDiana  DRPoiatti  RMatteucci  AChioda  CGiovanetti  M Occasional finding of mesenteric lipodystrophy during laparoscopy: a difficult diagnosis. World J Gastroenterol 2007;13 (40) 5394- 5396
PubMed
White  JW  JrWinkelmann  RK Weber-Christian panniculitis: a review of 30 cases with this diagnosis. J Am Acad Dermatol 1998;39 (1) 56- 62
PubMed Link to Article
Al-Niaimi  FClark  CThorrat  ABurden  AD Idiopathic lobular panniculitis: remission induced and maintained with infliximab. Br J Dermatol 2009;161 (3) 691- 692
PubMed Link to Article
Requena  LYus  ES Panniculitis, I: mostly septal panniculitis. J Am Acad Dermatol 2001;45 (2) 163- 186
PubMed Link to Article
Carrasco  LMoreno  CPastor  MA  et al.  Postirradiation pseudosclerodermatous panniculitis. Am J Dermatopathol 2001;23 (4) 283- 287
PubMed Link to Article
Thiers  BHSahn  RECallen  JP Cutaneous manifestations of internal malignancy. CA Cancer J Clin 2009;59 (2) 73- 98
PubMed Link to Article
Sabaté  JMTorrubia  SMaideu  JFranquet  TMonill  JMPérez  C Sclerosing mesenteritis: imaging findings in 17 patients. AJR Am J Roentgenol 1999;172 (3) 625- 629
PubMed Link to Article
Kipfer  REMoertel  CGDahlin  DC Mesenteric lipodystrophy. Ann Intern Med 1974;80 (5) 582- 588
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

A 68-year-old woman with sclerosing mesenteritis. A, Subcutaneous nodule on the right posterolateral arm exhibits a central fibrous depression with overlying peau d’orange surface changes and lateral retraction. B, Two well-circumscribed plaques on the right lower abdomen with sclerodermoid induration and hyperpigmentation along the borders.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Cutaneous sign of mesenteric sclerosis. A, Cutaneous sclerosis: well-demarcated islands of subcutaneous sclerosis with almost total envelopment of normal adipose tissue (hematoxylin-eosin, original magnification ×2). B, Cutaneous sclerosis: zones of woody sclerosis with contiguous fat necrosis and a mild lymphohistiocytic response (hematoxylin-eosin, original magnification ×10). C, Sclerosing mesenteritis: florid woody sclerosis predominates over mesenteric fat necrosis (hematoxylin-eosin, original magnification ×4). D, Sclerosing mesenteritis: dense sclerotic collagen bundles in whorled arrangement with foci of mesenteric fat necrosis and a scant lymphocytic response (hematoxylin-eosin, original magnification ×10).

Graphic Jump Location

Tables

References

Chawla  SYalamarthi  SShaikh  IATagore  VSkaife  P An unusual presentation of sclerosing mesenteritis as pneumoperitoneum: case report with a review of the literature. World J Gastroenterol 2009;15 (1) 117- 120
PubMed Link to Article
Edwards  MASmith  MParker  WGu  K Mesenteric lipodystrophy of the left colon. Am Surg 2007;73 (12) 1242- 1244
PubMed
Jura  V Sulla mesenterite e sclerosante. Il Policlinico (Sezione practica) 1924;31575
Emory  TSMonihan  JMCarr  NJSobin  LH Sclerosing mesenteritis, mesenteric panniculitis and mesenteric lipodystrophy: a single entity? Am J Surg Pathol 1997;21 (4) 392- 398
PubMed Link to Article
Plasencia  L DelgadoRodríguez Ballester  LLópez-Tomassetti Fernández  EMHernández Morales  ACarrillo Pallarés  AHernández Siverio  N Mesenteric panniculitis: experience in our center [in Spanish]. Rev Esp Enferm Dig 2007;99 (5) 291- 297
PubMed
Béchade  DDurand  XDesramé  J  et al.  Etiologic spectrum of mesenteric panniculitis: report of 7 cases [in French]. Rev Med Interne 2007;28 (5) 289- 295
PubMed Link to Article
McCrystal  DJO’Loughlin  BSSamaratunga  H Mesenteric panniculitis: a mimic of malignancy. Aust N Z J Surg 1998;68 (3) 237- 239
PubMed Link to Article
Akram  SPardi  DSSchaffner  JASmyrk  TC Sclerosing mesenteritis: clinical features, treatment, and outcome in ninety-two patients. Clin Gastroenterol Hepatol 2007;5 (5) 589- 596
PubMed Link to Article
Adachi  YMori  MEnjoji  MUeo  HSugimachi  K Mesenteric panniculitis of the colon: review of the literature and report of two cases. Dis Colon Rectum 1987;30 (12) 962- 966
PubMed Link to Article
Parra-Davila  EMcKenney  MGSleeman  D  et al.  Mesenteric panniculitis: case report and literature review. Am Surg 1998;64 (8) 768- 771
PubMed
Lim  CSRanger  G SinghTibrewal  SJani  BJeddy  TALafferty  K Sclerosing mesenteritis presenting with small bowel obstruction and subsequent retroperitoneal fibrosis. Eur J Gastroenterol Hepatol 2006;18 (12) 1285- 1287
PubMed Link to Article
Sharma  VMartin  PMarjoniemi  VM Idiopathic orbital inflammation with sclerosing mesenteritis: a new association? Clin Experiment Ophthalmol 2006;34 (2) 190- 192
PubMed Link to Article
Wat  SYHarish  SWinterbottom  AChoudhary  AKFreeman  AH The CT appearances of sclerosing mesenteritis and associated diseases. Clin Radiol 2006;61 (8) 652- 658
PubMed Link to Article
Al-Harthy  FEsdaile  JBerean  KWChalmers  A Multifocal idiopathic fibrosclerosis: treatment of 2 cases with cyclosporine. J Rheumatol 2006;33 (2) 358- 361
PubMed
Issa  IBaydoun  H Mesenteric panniculitis: various presentations and treatment regimens. World J Gastroenterol 2009;15 (30) 3827- 3830
PubMed Link to Article
Daskalogiannaki  MVoloudaki  APrassopoulos  P  et al.  CT evaluation of mesenteric panniculitis: prevalence and associated diseases. AJR Am J Roentgenol 2000;174 (2) 427- 431
PubMed Link to Article
Kelly  JKHwang  WS Idiopathic retractile (sclerosing) mesenteritis and its differential diagnosis. Am J Surg Pathol 1989;13 (6) 513- 521
PubMed Link to Article
Vettoretto  NDiana  DRPoiatti  RMatteucci  AChioda  CGiovanetti  M Occasional finding of mesenteric lipodystrophy during laparoscopy: a difficult diagnosis. World J Gastroenterol 2007;13 (40) 5394- 5396
PubMed
White  JW  JrWinkelmann  RK Weber-Christian panniculitis: a review of 30 cases with this diagnosis. J Am Acad Dermatol 1998;39 (1) 56- 62
PubMed Link to Article
Al-Niaimi  FClark  CThorrat  ABurden  AD Idiopathic lobular panniculitis: remission induced and maintained with infliximab. Br J Dermatol 2009;161 (3) 691- 692
PubMed Link to Article
Requena  LYus  ES Panniculitis, I: mostly septal panniculitis. J Am Acad Dermatol 2001;45 (2) 163- 186
PubMed Link to Article
Carrasco  LMoreno  CPastor  MA  et al.  Postirradiation pseudosclerodermatous panniculitis. Am J Dermatopathol 2001;23 (4) 283- 287
PubMed Link to Article
Thiers  BHSahn  RECallen  JP Cutaneous manifestations of internal malignancy. CA Cancer J Clin 2009;59 (2) 73- 98
PubMed Link to Article
Sabaté  JMTorrubia  SMaideu  JFranquet  TMonill  JMPérez  C Sclerosing mesenteritis: imaging findings in 17 patients. AJR Am J Roentgenol 1999;172 (3) 625- 629
PubMed Link to Article
Kipfer  REMoertel  CGDahlin  DC Mesenteric lipodystrophy. Ann Intern Med 1974;80 (5) 582- 588
PubMed Link to Article

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