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Correspondence |

Failed Treatment of Amelanotic Lentigo Maligna With Imiquimod Followed by Pigment Production

Kathryn J. Martires, BA; Laura Capaldi, MD; Sean F. Pattee, MD; Mary E. Maloney, MD; Jeremy S. Bordeaux, MD, MPH
Arch Dermatol. 2010;146(9):1047-1048. doi:10.1001/archdermatol.2010.237.
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A melanotic lentigo maligna (ALM) represents a small subset of lentigo maligna (LM) that lacks pigment. At least 2 cases of ALM responsive to imiquimod therapy with short-term follow-up have been reported.1 We report herein a case of ALM that failed to respond to imiquimod treatment. Furthermore, after therapy was initiated, the ALM began to produce pigment and transformed to LM.

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PubMed Link to Article[[XSLOpenURL/10.1016/j.jaad.2003.11.057]]
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PubMed Link to Article[[XSLOpenURL/10.1016/S0190-9622(97)70114-2]]
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PubMed Link to Article[[XSLOpenURL/10.1111/bjd.2006.155.issue-4]]
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PubMed Link to Article[[XSLOpenURL/10.1001/archderm.142.12.1551]]
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Lesion before (A) and after (B) imiquimod treatment. A, Clinical image of amelanotic lentigo maligna on the medial and lateral nasal sidewall (subsequently confirmed by biopsy). B, Lentigo maligna with pigment production after treatment with imiquimod.

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