Financial Disclosure: Dr Krueger has received fees as a consultant or advisory board member for Abbott, Almirall, Alza, Amgen, Anacor, Astellas, Barrier Therapeutics, Boehringer Ingelheim, Bristol-Myers Squibb, Centocor, CombinatoRx, Exelixis, Genentech, Genzyme, Isis, L’Oreal, Lupin Limited, Magen Biosciences, MedaCorp, Medicis, Novartis, Novo Nordisk, Schering Plough, Somagenics, theDerm.org, Synvista, Warner Chilcott, UCB, USANA Health Sciences, and ZARS. Dr Krueger owns equities and stock options in and/or from ZARS. In the last 24 months Dr Krueger has received lecture fees from Abbott, Amgen, Astellas, Boehringer Ingelheim, Centocor, Connetics, National Psoriasis Foundation, The Foundation for Better Health Care, and Warner Chilcott. Dr Krueger has received partial stipend support for a clinical research fellowship from Abbott, Amgen, and Centocor. Dr Callis Duffin is on the speakers' bureau for Amgen, Abbott, and Centocor. She has been a consultant and advisor for Amgen, Pfizer, Wyeth, Bristol-Meyers Squibb, Genzyme, Novo Nordisk, VBL Therapeutics, and Eli Lilly. Dr Callis Duffin has been an investigator for Amgen, Abbott, Centocor, Pfizer, Wyeth, Genzyme, Novo Nordisk, VBL Therapeutics, Eli Lilly, Incyte, and Graceway.