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Correspondence |

Durable Complete Remission of Therapy-Refractory, Tumor-Stage Cutaneous T-Cell Lymphoma Under Radioimmunotherapy With Electron Beam Irradiation and Denileukin Diftitox

Marion Wobser, MD; Daniela Göppner, MD; Sabrina C. Lang, MD; Gabriele Beckmann, MD; Michael Flentje, MD; Selma Ugurel, MD; Eva-B. Bröcker, MD; Jürgen C. Becker, MD, PhD
Arch Dermatol. 2010;146(7):805-806. doi:10.1001/archdermatol.2010.147.
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Cutaneous T-cell lymphoma treated in the early stages has an excellent prognosis. However, in advanced stages, the prognosis is fatal; therapeutic response rates are low; and quality of life is severely reduced. Hence, a therapy that achieves a substantial and long-lasting down-staging of tumor burden in the advanced stages is warranted.

Wong  BYGregory  SADang  NH Denileukin diftitox as novel targeted therapy for lymphoid malignancies. Cancer Invest 2007;25 (6) 495- 501
PubMed Link to Article[[XSLOpenURL/10.1080/07357900701360096]]
Olsen  EDuvic  MFrankel  A  et al.  Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma. J Clin Oncol 2001;19 (2) 376- 388
PubMed
Hoppe  RTFuks  ZBagshaw  MA The rationale for curative radiotherapy in mycosis fungoides. Int J Radiat Oncol Biol Phys 1977;2 (9-10) 843- 851
PubMed Link to Article[[XSLOpenURL/10.1016/0360-3016(77)90182-1]]
Cotter  GWBaglan  RJWasserman  THMill  W Palliative radiation treatment of cutaneous mycosis fungoides: a dose response. Int J Radiat Oncol Biol Phys 1983;9 (10) 1477- 1480
PubMed Link to Article[[XSLOpenURL/10.1016/0360-3016(83)90321-8]]
Funk  AHensley  FKrempien  R  et al.  Palliative total skin electron beam therapy (TSEBT) for advanced cutaneous T-cell lymphoma. Eur J Dermatol 2008;18 (3) 308- 312
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Clinical images taken before (A and B) and after (C and D) treatment with 2 courses of denileukin diftitox and electron beam irradiation. A and B, Disseminated tumors of cutaneous T-cell lymphoma (mycosis fungoides) on the trunk and extremities before treatment. C and D, Residual disease with disseminated plaques and patches but without any tumors after treatment. Ultimately the patient experienced histologically proven complete remission.

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