Correspondence |

Value of the Detection of Circulating Antibodies Against BP Antigens in Unaffected Subjects—Reply

Carilyn N. Wieland, MD; Nneka I. Comfere, MD; Lawrence E. Gibson, MD; Amy L. Weaver, MS; Patricia K. Krause, MS, MBA; Joseph A. Murray, MD
Arch Dermatol. 2010;146(7):802. doi:10.1001/archdermatol.2010.148.
Text Size: A A A
Published online


In reply

We appreciate the comments of Foureur et al regarding possible associations between BP and neurologic diseases. We also debated whether the false-positive cases in our study could have potential clinical significance and agree that patients testing positive for anti-BP antibodies without clinical evidence of BP should be further studied for relevant clinical disease associations.

Our article commented specifically on the cutaneous and autoimmune medical histories; however, the initial chart review included all major clinical diagnoses from the subjects who tested positive. Five of the 25 patients who tested positive had neurologic diseases listed in the medical record, including migraines (a 25-year-old woman), narcolepsy (a 46-year-old man), Lewy body dementia (a 68-year-old man and a 93-year-old man), and Alzheimer dementia (an 86-year-old woman). The positive cases with dementia were all diagnosed in conjunction with neurology consultation, and the 2 younger subjects with dementia also underwent formal neuropsychometric testing. We agree with Foureur et al that the link between anti-BP antibodies and neurologic diseases is an important clinical question, and as a result, we intend to study the potential clinical significance of anti-BP antibodies.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles