Treatment of GMF was heterogeneous, involving combined treatment with psoralen–UV-A and interferon alfa in 7 patients. Three patients received chemotherapy with the CHOP regimen (cyclophosphamide, doxorubicin, vincristine sulfate, and prednisolone acetate), whereas 2 patients were treated with single-agent chemotherapy. Radiation was applied in 7 of 15 patients. Other treatment modalities included topical corticosteroids, imiquimod, and systemic retinoids. Complete tumor regression was observed in only 3 of 15 patients (20%), but recurrence developed within 2 years in 1 patient. In both patients with complete remission, the remission followed treatment with interferon alfa. Progression of the disease was observed in 6 of 15 patients (40%), and extracutaneous spread was observed in 5 (33%) with involvement of lymph nodes, liver, and bone marrow (Table 1). In 3 of 15 patients (20%), transformation into CD30+ large-cell phenotype was observed. Six of 15 patients (40%), including the 3 patients with transformation into a CD30+ large-cell phenotype, died of lymphoma after a median follow-up of 5.3 years (range, 1-20 years) after diagnosis and 16 years (range, 2-54 years) after onset of the disease, ie, the appearance of first symptoms. Disease-specific 5-year survival rate in GMF was 66%.