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Two Pediatric Cases of Nonbullous Histiocytoid Neutrophilic Dermatitis Presenting as a Cutaneous Manifestation of Lupus Erythematosus FREE

Diana Camarillo, MD; Timothy H. McCalmont, MD; Ilona J. Frieden, MD; Amy E. Gilliam, MD
[+] Author Affiliations

Author Affiliations: Departments of Dermatology (Drs Camarillo, McCalmont, Frieden, and Gilliam), Pathology (Dr McCalmont), and Pediatrics (Drs Camarillo, Frieden, and Gilliam), and San Francisco Dermatopathology Service (Dr McCalmont), University of California, San Francisco.


Arch Dermatol. 2008;144(11):1495-1498. doi:10.1001/archderm.144.11.1495.
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Published online

ABSTRACT

Background  Nonbullous neutrophilic dermatoses are seen infrequently in association with lupus erythematosus (LE). A recently described histopathologic variant of Sweet syndrome, to our knowledge, histiocytoid Sweet syndrome (HSS) has not been described in either pediatric or adult patients with LE.

Observations  We describe 2 pediatric patients with nonbullous histiocytoid neutrophilic dermatitis in the setting of LE. One case represents the initial presentation of subacute cutaneous LE, while the other case represents a manifestation of established systemic LE. Both cases demonstrate histopathologic findings of HSS.

Conclusions  We believe that the dermatosis observed in these 2 patients represents a nonbullous histiocytoid neutrophilic dermatosis that is best termed HSS. This entity may represent a distinct and important cutaneous manifestation of LE. Additional study is needed to further elucidate the relationship between neutrophilic dermatitis and LE.

Figures in this Article

We describe 2 pediatric patients with nonbullous neutrophilic dermatitis presenting as a cutaneous manifestation of lupus erythematosus (LE). Both cases demonstrated unique histopathologic features that resembled a variant of neutrophilic dermatosis recently coined histiocytoid Sweet syndrome (HSS).1 However, the clinical presentation of these 2 patients was not typical of conventional Sweet syndrome.

REPORT OF CASES

CASE 1

A 9-year-old girl with systemic LE (SLE) presented with a 2-month history of an asymptomatic eruption on the upper and lower extremities. The patient reportedly had experienced a “stomach flu” associated with fever prior to the onset of the eruption. She denied other systemic symptoms. Her medical history was significant for mesangial glomerulonephritis, malar eruption, and atopic dermatitis. Her medications included prednisone, mycophenolate mofetil, hydroxychloroquine, and aspirin, all of which she had been taking for more than 6 months prior to the onset of the eruption.

Physical examination revealed scattered blanching violaceous papules and macules, some of which coalesced into plaques on the palms, arms, thighs, and buttocks. (Figure 1A). She also had erythematous confluent patches on the malar eminences.

Place holder to copy figure label and caption
Figure 1.

Systemic lupus erythematosus, patient 1. A, Blanching violaceous papules and macules present on the upper and lower extremities. B, Interstitial reticular dermal infiltrate of neutrophils, leukocytoclastic debris, and cells with histiocytelike morphologic characteristics (hematoxylin-eosin, original magnification ×100). Immunoperoxidase staining (inset) reveals diffuse expression of CD68 and myeloperoxidase, confirming myelocytic lineage (myeloperoxidase, original magnification ×400).

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Laboratory examinations performed on initial presentation revealed a normal white blood cell count with lymphopenia, hypocomplementemia, and an elevated double-stranded DNA level of 790 IU/mL (normal, <25 IU/mL). Erythrocyte sedimentation rate and C-reactive protein level were also both elevated at 40 mm/h (normal, <15 mm/h) and 9.4 mg/L (normal, <6.3 mg/mL) respectively. (To convert C-reactive protein to nanomoles per liter, multiply by 9.524.)

A skin biopsy specimen revealed an interstitial dermal infiltrate of histiocytelike cells and lymphocytes coupled with segmented neutrophils and scant leukocytoclastic debris. Focal dermal edema was also noted. There was no evidence of vasculitis or vacuolar alteration at the dermoepidermal junction (Figure 1B). A colloidal iron stain showed an increase in dermal mucin. Immunoperoxidase staining revealed that the histiocytelike cells showed avid expression of myeloperoxidase and CD68, suggesting myeloid lineage (Figure 1B, inset). Results for CD20 stain were negative, indicating that B cells were absent. Direct immunoflourescence (DIF) findings were negative for evidence of immunoreactant deposition along the dermopidermal junction or in the vicinity of blood vessels. However, the DIF slides did reveal nuclear staining with IgG of keratinocytes, consistent with the positive results of an antinuclear antibody test and the presence of anti–ribonucleoprotein antibodies, which this patient had.

Treatment was initiated with pulsed methylprednisolone and dapsone. The patient responded well to the corticosteroids and experienced a slow but almost complete response to dapsone after 6 months of therapy.

CASE 2

A previously healthy 5-year-old girl presented with an asymptomatic facial eruption of several months' duration. It initially appeared on the ears and eventually spread to involve the nasal bridge and malar cheeks. She had no systemic symptoms. She had received multiple courses of antibiotics for presumed cellulitis, but the eruptions seemed to resolve and recur on average every 3 months regardless of antibiotic treatment.

Physical examination findings revealed well-defined erythematous plaques of the helix, both annular and linear in configuration. There were several arcuate edematous and erythematous plaques with overlying crust extending over the nasal bridge onto the malar cheeks. (Figure 2A).

Place holder to copy figure label and caption
Figure 2.

Subacute cutaneous lupus erythematosus, patient 2. A, Arcuate erythematous crusted plaques on the malar cheeks and nasal bridge. B, Diffuse reticular dermal infiltrate with no associated epidermal alteration (hematoxylin-eosin, original magnification ×40). At high magnification (inset), the infiltrate includes many cells with histiocytelike morphologic characteristics as well as mature neutrophils and leukocytoclastic debris (hematoxylin-eosin, original magnification ×400).

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Initial laboratory examination revealed a normal white blood cell count and normal hemoglobin and complement levels. Findings for anti–Sjögren syndrome antigen B antibody were positive, with the relative antibody titer index higher than 5 (normal, <1). Serologic findings were initially negative for anti–Sjögren syndrome antigen A antibody, antinuclear antibody, and anti–double-stranded DNA.

Histopathologic examination of a skin biopsy specimen from the right ear revealed an interstitial and diffuse dermal infiltrate, including segmented neutrophils, scant leukocytoclastic debris, lymphocytes, and monocytoid cells that resembled histiocytes (Figure 2B). There was a sparse lobular infiltrate of similar composition in the subjacent panniculus. No significant vacuolar alteration was seen. Findings from DIF staining were negative.

A presumed diagnosis of subacute cutaneous lupus erythematosus was made based on the clinical findings and positive Sjögren syndrome antigen B results. The patient was treated with hydroxychloroquine, and the skin lesions resolved. One year later, antinuclear antibody testing was repeated, and the titer was found to be 1:320 with a speckled pattern. Sjögren syndrome antigen A results were also positive at this time, with a value higher than 5 (normal, <1).

COMMENT

Neutrophilic dermatoses are commonly seen in association with connective tissue disease, but they are infrequently reported as a manifestation of LE. Bullous SLE is a well-documented but rare neutrophilic dermatosis that manifests as a vesiculobullous eruption in the setting of SLE. Palisaded neutrophilic granulomatous dermatitis (PNGD), also known as interstitial granulomatous dermatitis with arthritis, represents an uncommon condition characterized by a nonbullous symmetric papular eruption and has been described as a manifestation of connective tissue disease, including LE.2 One case of PNGD in a pediatric patient with LE has been reported.3 In addition, isolated case reports of pyoderma gangrenosum in association with SLE are described in the literature.4,5

Sweet syndrome and Sweet-like eruptions with histopathologic findings including a diffuse neutrophilic infiltrate and papillary dermal edema have also been described as uncommon manifestations of LE.613 However, many of the patients with LE who present with these neutrophil-rich eruptions do not meet the diagnostic criteria for classic Sweet syndrome. Gleason et al6 have postulated that this nonbullous neutrophilic dermatosis, or Sweet-like eruption, is an underrecognized variant of cutaneous LE.

Of interest, the histopathologic findings of all cases of neutrophilic dermatosis in the context of established LE suggested LE.5,7,8 Conversely, the biopsy specimens from patients with no history of LE did not reveal such findings. Consistent with these reports, the biopsy specimen from our patient 1, who had prior SLE, showed an increase in dermal mucin and nuclear IgG staining on DIF, while the biopsy specimen from patient 2, who did not carry a diagnosis of LE at the time of presentation, did not show findings suggestive of LE.

One of the distinctive aspects of our 2 pediatric LE cases is that the histopathologic findings in both revealed not only interstitial and diffuse infiltrates of segmented neutrophils but also monocytoid cells resembling histiocytes. These histiocytelike cells were confirmed to be of myeloid lineage by positive staining for myeloperoxidase and CD68. In 2005, Requena et al1 first coined the term histiocytoid Sweet syndrome, thus expanding the spectrum of histopathologic findings.1 They described 41 cases of cutaneous lesions consistent with Sweet syndrome in which biopsy specimens showed cutaneous infiltrates, including many histiocytelike cells that were confirmed to be of myeloid lineage by immunohistochemical analysis. Six of the 41 patients had associated malignant neoplasms. None of the patients were children. The course of the disease was similar to that of classic Sweet syndrome, with prompt resolution of the cutaneous lesions after administration of systemic corticosteroid therapy. Chow et al14 more recently elaborated on this phenomenon as they reported 6 additional cases of inflammatory skin disease characterized by dermal and/or subcutaneous infiltrates of histiocytoid myeloid cells. Most of their cases did not fulfill the strict criteria for a diagnosis of classic Sweet syndrome, and therefore they referred to this spectrum of observations as “histiocytoid neutrophilic dermatoses and panniculitidies.”14

Although the histopathologic findings from both of our pediatric patients with LE were consistent with HSS as described by Requena et al,1 the criteria for a diagnosis of Sweet syndrome were not met by either of our patients.15,16 In addition, because the clinical picture of our patients was not typical of classic Sweet syndrome, we do not believe that Sweet-like represents the best descriptive term for these 2 cases. We have chosen the designation nonbullous histiocytoid neutrophilic dermatitis to generally describe the observed cases in this report, which we believe is both descriptive and accurate.

The presence of an interstitial infiltrate of histiocytoid myeloid cells in the setting of connective tissue disease raises a differential diagnosis that includes interstitial granulomatous dermatitis and interstitial granuloma annulare (Table). Interstitial granulomatous dermatitis differs histopathologically from HSS and nonbullous histiocytoid neutrophilic dermatitis in that it is characterized by a mixed infiltrate that includes both histiocytes and neutrophils, with histiocytes sometimes palisaded around foci rich in neutrophils or around a vasculitic nidus. The clinical morphologic characteristics of interstitial granulomatous dermatitis also differ from those observed in our patients. In interstitial granuloma annulare, the infiltrate is composed of authentic histiocytes rather than histiocytoid myeloid cells, and thus the findings are distinct from HSS nonbullous histiocytoid neutrophilic dermatitis, both histopathologically and immunohistochemically.

Table Graphic Jump LocationTable. Neutrophilic and Histiocytic Disorders Within the Differential Diagnosis of Nonbullous Histiocytoid Neutrophilic Dermatitisa

In conclusion, we report 2 pediatric cases of a nonbullous neutrophilic dermatitis, a variant of the recently described HSS, presenting as a cutaneous manifestation of LE. We believe that these cases further support the conclusions of Gleason et al,6 that nonbullous neutrophilic dermatitis should be considered a possible skin manifestation of LE. Moreover, the histopathologic findings of a histiocytoid neutrophilic dermal infiltrate may represent an important clue to the diagnosis of LE.

ARTICLE INFORMATION

Correspondence: Amy E. Gilliam, MD, Palo Alto Medical Foundation, 795 El Camino Real, Clark Bldg, Palo Alto, CA 94301 (Gilliam@derm.ucsf.edu).

Accepted for Publication: February 19, 2008.

Author Contributions:Study concept and design: Camarillo and Gilliam. Acquisition of data: Camarillo, McCalmont, Frieden, and Gilliam. Analysis and interpretation of data: Camarillo, McCalmont, and Gilliam. Drafting of the manuscript: Camarillo and Gilliam. Critical revision of the manuscript for important intellectual content: McCalmont, Frieden, and Gilliam. Study supervision: McCalmont, Frieden, and Gilliam.

Financial Disclosure: None reported.

REFERENCES

Requena  LKutzner  HPalmedo  G  et al.  Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. Arch Dermatol 2005;141 (7) 834- 842
PubMed Link to Article
Chu  PConnolly  MKLeBoit  PE The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol 1994;130 (10) 1278- 1283
PubMed Link to Article
Germanas  JPMehrabi  DCarder  KR Palisaded neutrophilic granulomatous dermatitis in a 12-year-old girl with systemic lupus erythematosus. J Am Acad Dermatol 2006;55 (2) ((suppl)) S60- S62
PubMed Link to Article
Waldman  MACallen  JP Pyoderma gangrenosum preceding the diagnosis of systemic lupus erythematosus. Dermatology 2005;210 (1) 64- 67
PubMed Link to Article
Reddy  VDziadzio  MHamdulay  SBoyce  SPrasad  NKeat  A Lupus and leg ulcers: a diagnostic quandary. Clin Rheumatol 2007;26 (7) 1173- 1175
PubMed Link to Article
Gleason  BCZembowicz  AGranter  SR Non-bullous neutrophilic dermatosis: an uncommon dermatologic manifestation in patients with lupus erythematosus. J Cutan Pathol 2006;33 (11) 721- 725
PubMed Link to Article
Hou  TYChang  DMGao  HWChen  CHChen  HCLai  JH Sweet syndrome as an initial presentation in systemic lupus erythematosus: a case report and review of the literature. Lupus 2005;14 (5) 399- 402
PubMed Link to Article
Goette  DK Sweet syndrome in subacute cutaneous lupus erythematosus. Arch Dermatol 1985;121 (6) 789- 791
PubMed Link to Article
Choi  JWChung  KY Sweet syndrome with systemic lupus erythematosus and herpes zoster. Br J Dermatol 1999;140 (6) 1174- 1175
PubMed
Ramsey-Goldman  RFranz  TSolano  FXMedsger  TA  Jr Hydralazine induced lupus and Sweet's syndrome. J Rheumatol 1990;17 (5) 682- 684
PubMed
Sequeira  WPolisky  RBAlrenga  DP Neutrophilic dermatosis (Sweet syndrome): association with a hydralazine-induced lupus syndrome. Am J Med 1986;81 (3) 558- 560
PubMed Link to Article
Servitje  ORibera  MJuanola  XRodriguez-Moreno  J Acute neutrophilic dermatosis associated with hydralazine-induced lupus. Arch Dermatol 1987;123 (11) 1435- 1436
PubMed Link to Article
Burnham  JMCron  RQ Sweet syndrome as an initial presentation in a child with systemic lupus erythematosus. Lupus 2005;14 (12) 974- 975
PubMed Link to Article
Chow  SPasternak  SGreen  P  et al.  Histiocytoid neutrophilic dermatoses and panniculitides: variations on a theme. Am J Dermatopathol 2007;29 (4) 334- 341
PubMed Link to Article
von den Driesch  P Sweet's syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol 1994;31 (4) 535- 556
PubMed Link to Article
Su  WPLiu  HN Diagnostic criteria for Sweet's syndrome. Cutis 1986;37 (3) 167- 174
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

Systemic lupus erythematosus, patient 1. A, Blanching violaceous papules and macules present on the upper and lower extremities. B, Interstitial reticular dermal infiltrate of neutrophils, leukocytoclastic debris, and cells with histiocytelike morphologic characteristics (hematoxylin-eosin, original magnification ×100). Immunoperoxidase staining (inset) reveals diffuse expression of CD68 and myeloperoxidase, confirming myelocytic lineage (myeloperoxidase, original magnification ×400).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Subacute cutaneous lupus erythematosus, patient 2. A, Arcuate erythematous crusted plaques on the malar cheeks and nasal bridge. B, Diffuse reticular dermal infiltrate with no associated epidermal alteration (hematoxylin-eosin, original magnification ×40). At high magnification (inset), the infiltrate includes many cells with histiocytelike morphologic characteristics as well as mature neutrophils and leukocytoclastic debris (hematoxylin-eosin, original magnification ×400).

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Neutrophilic and Histiocytic Disorders Within the Differential Diagnosis of Nonbullous Histiocytoid Neutrophilic Dermatitisa

References

Requena  LKutzner  HPalmedo  G  et al.  Histiocytoid Sweet syndrome: a dermal infiltration of immature neutrophilic granulocytes. Arch Dermatol 2005;141 (7) 834- 842
PubMed Link to Article
Chu  PConnolly  MKLeBoit  PE The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. Arch Dermatol 1994;130 (10) 1278- 1283
PubMed Link to Article
Germanas  JPMehrabi  DCarder  KR Palisaded neutrophilic granulomatous dermatitis in a 12-year-old girl with systemic lupus erythematosus. J Am Acad Dermatol 2006;55 (2) ((suppl)) S60- S62
PubMed Link to Article
Waldman  MACallen  JP Pyoderma gangrenosum preceding the diagnosis of systemic lupus erythematosus. Dermatology 2005;210 (1) 64- 67
PubMed Link to Article
Reddy  VDziadzio  MHamdulay  SBoyce  SPrasad  NKeat  A Lupus and leg ulcers: a diagnostic quandary. Clin Rheumatol 2007;26 (7) 1173- 1175
PubMed Link to Article
Gleason  BCZembowicz  AGranter  SR Non-bullous neutrophilic dermatosis: an uncommon dermatologic manifestation in patients with lupus erythematosus. J Cutan Pathol 2006;33 (11) 721- 725
PubMed Link to Article
Hou  TYChang  DMGao  HWChen  CHChen  HCLai  JH Sweet syndrome as an initial presentation in systemic lupus erythematosus: a case report and review of the literature. Lupus 2005;14 (5) 399- 402
PubMed Link to Article
Goette  DK Sweet syndrome in subacute cutaneous lupus erythematosus. Arch Dermatol 1985;121 (6) 789- 791
PubMed Link to Article
Choi  JWChung  KY Sweet syndrome with systemic lupus erythematosus and herpes zoster. Br J Dermatol 1999;140 (6) 1174- 1175
PubMed
Ramsey-Goldman  RFranz  TSolano  FXMedsger  TA  Jr Hydralazine induced lupus and Sweet's syndrome. J Rheumatol 1990;17 (5) 682- 684
PubMed
Sequeira  WPolisky  RBAlrenga  DP Neutrophilic dermatosis (Sweet syndrome): association with a hydralazine-induced lupus syndrome. Am J Med 1986;81 (3) 558- 560
PubMed Link to Article
Servitje  ORibera  MJuanola  XRodriguez-Moreno  J Acute neutrophilic dermatosis associated with hydralazine-induced lupus. Arch Dermatol 1987;123 (11) 1435- 1436
PubMed Link to Article
Burnham  JMCron  RQ Sweet syndrome as an initial presentation in a child with systemic lupus erythematosus. Lupus 2005;14 (12) 974- 975
PubMed Link to Article
Chow  SPasternak  SGreen  P  et al.  Histiocytoid neutrophilic dermatoses and panniculitides: variations on a theme. Am J Dermatopathol 2007;29 (4) 334- 341
PubMed Link to Article
von den Driesch  P Sweet's syndrome (acute febrile neutrophilic dermatosis). J Am Acad Dermatol 1994;31 (4) 535- 556
PubMed Link to Article
Su  WPLiu  HN Diagnostic criteria for Sweet's syndrome. Cutis 1986;37 (3) 167- 174
PubMed

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