Cutaneous amebiasis (CA) is characterized by painful ulcers laden with trophozoites of Entamoeba histolytica that damage the skin and underlying soft tissues. Involvement may be limited to the skin or may include other organ systems such as the gastrointestinal tract, liver, lungs, and central nervous system. In this retrospective case series, Magaña et al describe 26 patients with cutaneous amebiasis, reporting patient demographics, associated illnesses, and diagnostic methods. Direct and indirect mechanisms for skin inoculation are described, and the authors suggest that CA be considered in the differential diagnosis of any ulcer in the diaper area of a child. Malnutrition, poor hygiene, and preexisting disease contribute to the development of CA in infants and small children, highlighting the public health importance of this condition.