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Correspondence |

Imatinib-Induced Hand-Foot Syndrome in a Patient With Metastatic Gastrointestinal Stromal Tumor

Maxime Battistella, MD; Guillemette Frémont, MD; Marie-Dominique Vignon-Pennamen, MD; Jean-Marc Gornet, MD; Louis Dubertret, MD, PhD; Manuelle Viguier, MD
Arch Dermatol. 2008;144(10):1400-1402. doi:10.1001/archderm.144.10.1400.
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Imatinib has become a main chemotherapeutic agent, especially for metastatic gastrointestinal stromal tumors (GISTs) and chronic myeloid leukemia. To our knowledge, we report herein the first case of hand-foot syndrome induced by this drug.

Scheinfeld  N Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. J Drugs Dermatol 2006;5 (3) 228- 231
Ayirookuzhi  SJMa  LRamshesh  PMills  G Imatinib-induced Sweet syndrome in a patient with chronic myeloid leukemia. Arch Dermatol 2005;141 (3) 368- 370
Deguchi  NKawamura  TShimizu  A  et al.  Imatinib mesylate causes palmoplantar hyperkeratosis and nail dystrophy in three patients with chronic myeloid leukaemia. Br J Dermatol 2006;154 (6) 1216- 1218
Robert  CSoria  JCSpatz  A  et al.  Cutaneous side-effects of kinase inhibitors and blocking antibodies. Lancet Oncol 2005;6 (7) 491- 500
PubMed Link to Article[[XSLOpenURL/10.1016/S1470-2045(05)70243-6]]
Adams  VRLeggas  M Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Clin Ther 2007;29 (7) 1338- 1353
PubMed Link to Article[[XSLOpenURL/10.1016/j.clinthera.2007.07.022]]
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Figure 1.

Tender edematous and painful erythema of the palm (A) and sole (B).

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Figure 2.

The lesional skin biopsy specimen shows upper epidermic necrosis and numerous necrotic keratinocytes of the underlying layers. The papular dermis contains moderate inflammatory infiltrate, mainly lymphocytic, with a perivascular pattern and some slight interface dermatitis lesions (hematoxylin-eosin, original magnification ×200).

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