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Correspondence |

Merkel Cell Carcinoma Presenting as Lymphadenopathy Without a Primary Cutaneous Lesion: A Report of 2 Cases

Meredith Warnick, MD; Saurabh Singh, MD; Marc E. Boisvert, MD; Gary L. Peck, MD
Arch Dermatol. 2008;144(10):1397-1398. doi:10.1001/archderm.144.10.1397.
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Merkel cell carcinoma (MCC) is an aggressive, uncommon, neuroendocrine malignant neoplasm of the skin. There have been rare reports of MCC presenting as lymphadenopathy with no apparent cutaneous primary lesion.1 This may result from complete regression of a primary cutaneous MCC. Histologically, nodal MCC must be differentiated from other similar neuroendocrine malignant neoplasms.2 Herein, we describe 2 additional patients diagnosed as having MCC presenting only with lymphadenopathy.

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Figure 1.

Merkel cell carcinoma cells are present in an inguinal lymph node in case 1 (hematoxylin-eosin, original magnification ×40).

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Figure 2.

Merkel cell carcinoma cells in an inguinal lymph node are immunohistochemically stained with cytokeratin 20 in case 1 (original magnification ×40).

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